Labbé Simon
Simon Labbé, Department of Biochemistry, Faculty of Medicine, Université de Sherbrooke, 3001, 12e Avenue Nord, Sherbrooke J1H 5N4, Canada.
World J Biol Chem. 2010 May 26;1(5):196-200. doi: 10.4331/wjbc.v1.i5.196.
Iron and copper have a wealth of functions in biological systems, which makes them essential micronutrients for all living organisms. Defects in iron and copper homeostasis are directly responsible for diseases, and have been linked to impaired development, metabolic syndromes and fungal virulence. Consequently, it is crucial to gain a comprehensive understanding of the molecular bases of iron- and copper-dependent proteins in living systems. Simon Labbé maintains parallel programs on iron and copper homeostasis using the fission yeast Schizosaccharomyces pombe (Schiz. pombe) as a model system. The study of fission yeast transition-metal metabolism has been successful, not only in discerning the genes and pathways functioning in Schiz. pombe, but also the genes and pathways that are active in mammalian systems and for other fungi.
铁和铜在生物系统中具有多种功能，这使它们成为所有生物不可或缺的微量营养素。铁和铜稳态的缺陷直接导致疾病，并与发育受损、代谢综合征和真菌毒力有关。因此，全面了解生物系统中铁和铜依赖蛋白的分子基础至关重要。西蒙·拉贝以裂殖酵母粟酒裂殖酵母（裂殖酵母）为模型系统，开展了关于铁和铜稳态的平行研究项目。对裂殖酵母过渡金属代谢的研究取得了成功，不仅识别出了在裂殖酵母中发挥作用的基因和途径，还发现了在哺乳动物系统和其他真菌中活跃的基因和途径。
