Ween Miranda P, Oehler Martin K, Ricciardelli Carmela
Research Centre for Reproductive Health, School of Paediatrics and Reproductive Health, Robinson Institute, University of Adelaide, Adelaide, South Australia 5005, Australia; E-Mails:
Int J Mol Sci. 2011 Jan 31;12(2):1009-29. doi: 10.3390/ijms12021009.
There is increasing evidence to suggest that extracellular matrix (ECM) components play an active role in tumor progression and are an important determinant for the growth and progression of solid tumors. Tumor cells interfere with the normal programming of ECM biosynthesis and can extensively modify the structure and composition of the matrix. In ovarian cancer alterations in the extracellular environment are critical for tumor initiation and progression and intra-peritoneal dissemination. ECM molecules including versican and hyaluronan (HA) which interacts with the HA receptor, CD44, have been shown to play critical roles in ovarian cancer metastasis. This review focuses on versican, HA, and CD44 and their potential as therapeutic targets for ovarian cancer.
越来越多的证据表明，细胞外基质（ECM）成分在肿瘤进展中发挥积极作用，并且是实体瘤生长和进展的重要决定因素。肿瘤细胞干扰ECM生物合成的正常程序，并可广泛改变基质的结构和组成。在卵巢癌中，细胞外环境的改变对于肿瘤的起始、进展和腹膜播散至关重要。包括多功能蛋白聚糖和与透明质酸（HA）受体CD44相互作用的透明质酸（HA）在内的ECM分子已被证明在卵巢癌转移中起关键作用。本综述重点关注多功能蛋白聚糖、HA和CD44及其作为卵巢癌治疗靶点的潜力。
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