Andrews Jason R, Cho-Park Yoon Andrew, Ferry Judith, Abramson Jeremy S, Robbins Gregory K
Division of Infectious Diseases, Massachusetts General Hospital, 55 Fruit Street, Cox 506, Boston, MA 02114, USA.
AIDS Res Treat. 2011;2011:729854. doi: 10.1155/2011/729854. Epub 2011 Apr 3.
Since its discovery in 1994, Kaposi's sarcoma-associated herpesvirus (KSHV) has been associated with lymphoproliferative disorders, particularly in patients infected with human immunodeficiency virus (HIV). The disorders most strongly linked to KSHV are multicentric Castleman's Disease (MCD), primary effusion lymphoma, and diffuse large B-cell lymphomas. We report an unusual case of KSHV-associated lymphoma in an HIV-infected patient manifesting with myocardial and central nervous system involvement. We discuss this case in the context of increasing array of KSHV-associated lymphomas. In the HIV-infected patient with a mass lesion, a history of cutaneous Kaposi's sarcoma and prolonged immunosuppression should alert clinicians as to the possibility of KSHV-associated lymphoproliferative disorders, in order to establish a timely diagnosis.
自1994年发现以来，卡波西肉瘤相关疱疹病毒（KSHV）一直与淋巴增殖性疾病相关，尤其是在感染人类免疫缺陷病毒（HIV）的患者中。与KSHV联系最紧密的疾病是多中心Castleman病（MCD）、原发性渗出性淋巴瘤和弥漫性大B细胞淋巴瘤。我们报告了一例HIV感染患者发生的KSHV相关淋巴瘤的罕见病例，该患者表现为心肌和中枢神经系统受累。我们在越来越多的KSHV相关淋巴瘤的背景下讨论此病例。在有肿块病变的HIV感染患者中，有皮肤卡波西肉瘤病史和长期免疫抑制应提醒临床医生注意KSHV相关淋巴增殖性疾病的可能性，以便及时做出诊断。
