Niinaka Y, Oida S, Ishisaki A, Takeda K, Iimura T, Maruoka Y, Momose F, Negishi A, Ichijo H, Amagasa T, Sasaki S, Watanabe H, Raz A
KARMANOS CANC INST,TUMOR PROGRESS & METASTASIS PROGRAM,DETROIT,MI 48201. WAYNE STATE UNIV,DEPT RADIAT ONCOL,DETROIT,MI 48201. WAYNE STATE UNIV,DEPT PATHOL,DETROIT,MI 48201. UNIV TOKYO,FAC DENT,DEPT BIOCHEM,BUNKYO KU,TOKYO 113,JAPAN. UNIV TOKYO,FAC DENT,DEPT ORAL & MAXILLOFACIAL SURG,BUNKYO KU,TOKYO 113,JAPAN. TORIDE KYODO GEN HOSP,DEPT ORAL SURG,TORIDE,IBARAKI 302,JAPAN. GUNMA UNIV,SCH MED,DEPT ORTHOPAED SURG,MAEBASHI,GUMMA 371,JAPAN.
Int J Oncol. 1996 Sep;9(3):433-8. doi: 10.3892/ijo.9.3.433.
Autocrine motility factor (AMF) a tumor-secreted 55 kDa cytokine induces tumor cell motility by a signal transduction pathway mediated by interaction with its receptor (AMFR) a cell surface glycoprotein of 78 kDa (gp78). Here, AMF secreted by the metastatic LMF4 human oral squamous-cell carcinoma (SCC) cells, induced dose- and time-dependent morphological changes and chemotaxis of the producing cells. Expression of AMFR mRNA was associated with the metastatic ability of SCC cell variants. The data presented show for the first time that SCC cells produce AMF and express AMFR and the expression is related to their invasiveness and metastatic potentials.
自分泌运动因子（AMF）是一种由肿瘤分泌的55 kDa细胞因子，它通过与受体（AMFR）相互作用介导的信号转导途径诱导肿瘤细胞运动，AMFR是一种78 kDa的细胞表面糖蛋白（gp78）。在此，转移性LMF4人口腔鳞状细胞癌（SCC）细胞分泌的AMF诱导了产生细胞的剂量和时间依赖性形态变化及趋化性。AMFR mRNA的表达与SCC细胞变体的转移能力相关。所呈现的数据首次表明，SCC细胞产生AMF并表达AMFR，且这种表达与它们的侵袭性和转移潜能有关。
