van Blitterswijk C A, Grote J J
Department of Otorhinolaryngology, University Hospital Leiden, The Netherlands.
Ann Otol Rhinol Laryngol Suppl. 1990 Feb;144:3-11.
The biocompatibility of 11 porous canal wall prostheses and 4 dense incus prostheses, both types made of hydroxylapatite, was studied by light microscopy, scanning electron microscopy, transmission electron microscopy, and x-ray microanalysis. The duration of implantation varied between 4 and 40 months, and the 15 retrieved implants constitute 4% of the 375 clinically applied hydroxylapatite prostheses involved in this study. With respect to integration characteristics, coverage by epithelium and fibrous tissue, and biodegradation, the performance of clinically applied hydroxylapatite generally resembled that seen in animal experiments. However, the reactions during chronic infection in the human ear were more severe than those in experimentally induced acute infections in the rat middle ear. One of the canal wall prostheses showed trace element accumulation in the cytoplasm of phagocytes.
对11个羟基磷灰石制成的多孔耳道壁假体和4个致密砧骨假体的生物相容性进行了研究，研究方法包括光学显微镜、扫描电子显微镜、透射电子显微镜和X射线微量分析。植入时间在4至40个月之间，回收的15个植入物占本研究中375个临床应用的羟基磷灰石假体的4%。在整合特性、上皮和纤维组织覆盖以及生物降解方面，临床应用的羟基磷灰石的表现通常与动物实验中观察到的相似。然而，人耳慢性感染期间的反应比大鼠中耳实验性诱导的急性感染期间的反应更严重。其中一个耳道壁假体在吞噬细胞的细胞质中显示出微量元素积累。
