Schwager K
Klinik und Poliklinik für Hals-, Nasen- und Ohrenkranke der Universität Würzburg, Germany.
Am J Otol. 1998 Sep;19(5):569-73.
Titanium in other parts of the body, well known for its biocompatibility, was examined in an animal model for its use as an ossicular replacement material.
The biocompatibility of titanium was studied in the middle ear of rabbits using light and scanning electron microscopy. Titanium pins were placed as middle ear prostheses or as free implants and were examined after 28, 84, 168, and 336 days.
After 28 days, the prostheses were covered by regular mucosa. The free implants took up to 336 days to be totally epithelialized. There were no inflammatory cells observed on the surface of the material nor were unusual amounts of fibrous tissue seen. In addition, the titanium material exhibited an affinity toward bone.
The results of this animal experiment indicate that titanium is a useful material for ossicular replacement prostheses.
钛在身体其他部位因其生物相容性而闻名，本研究在动物模型中检测其作为听小骨替代材料的用途。
使用光学显微镜和扫描电子显微镜研究钛在兔中耳的生物相容性。将钛钉作为中耳假体或游离植入物放置，并在28、84、168和336天后进行检查。
28天后，假体被规则的黏膜覆盖。游离植入物需要336天才能完全上皮化。在材料表面未观察到炎性细胞，也未见异常数量的纤维组织。此外，钛材料对骨表现出亲和力。
该动物实验结果表明，钛是一种用于听小骨替代假体的有用材料。
