Division of Pharmaceutical Technology, Faculty of Pharmacy, University of Helsinki, Finland.
AAPS PharmSciTech. 2011 Jun;12(2):593-603. doi: 10.1208/s12249-011-9623-0. Epub 2011 May 4.
This study presents a new approach to model powder compression during tableting. The purpose of this study is to introduce a new discrete element simulation model for particle-particle bond formation during tablet compression. This model served as the basis for calculating tablet strength distribution during a compression cycle. Simulated results were compared with real tablets compressed from microcrystalline cellulose/theophylline pellets with various compression forces. Simulated and experimental compression forces increased similarly. Tablet-breaking forces increased with the calculated strengths obtained from the simulations. The calculated bond strength distribution inside the tablets showed features similar to those of the density and pressure distributions in the literature. However, the bond strength distributions at the center of the tablets varied considerably between individual tablets.
本研究提出了一种新的方法来模拟压片过程中的粉末压缩。本研究的目的是介绍一种新的离散元模拟模型，用于模拟片剂压缩过程中颗粒间键的形成。该模型可用于计算片剂在压缩周期内的强度分布。模拟结果与用不同压缩力从微晶纤维素/茶碱丸压制成的实际片剂进行了比较。模拟和实验的压缩力增加相似。片剂的破裂力随模拟得到的计算强度的增加而增加。片剂内部的结合强度分布显示出与文献中的密度和压力分布相似的特征。然而，片剂中心的结合强度分布在各个片剂之间有很大的差异。
