Medical Biotechnology Division, School of Bio-Sciences and Technology, VIT University, Vellore, India.
Appl Biochem Biotechnol. 2011 Sep;165(2):497-505. doi: 10.1007/s12010-011-9270-7. Epub 2011 May 4.
C-reactive protein (CRP) is a highly conserved plasma protein belonging to pentraxins, a superfamily which has significant proinflammatory role. Therefore, CRP can be a good target for drug discovery to prevent disease pathogenesis, especially cardioprotection in acute myocardial infarction and neuroprotection in stroke. Hence, the knowledge of the structure of CRP is very important. In this paper, we have demonstrated three-dimensional structure, conserved domains, and surface structure of human CRP with the help of bioinformatics analysis. We have also depicted that evolutionary relationship of CRP exists among the different species. Simultaneously, WebLogo has been generated to know the more conserved part of this medically important protein.
C-反应蛋白（CRP）是一种高度保守的血浆蛋白，属于五聚素超家族，具有重要的促炎作用。因此，CRP 可以成为药物发现的一个很好的靶点，以预防疾病的发病机制，特别是在急性心肌梗死中的心脏保护和在中风中的神经保护。因此，了解 CRP 的结构非常重要。在本文中，我们借助生物信息学分析，展示了人 CRP 的三维结构、保守结构域和表面结构。我们还描述了 CRP 在不同物种之间存在进化关系。同时，我们还生成了 WebLogo 来了解这个具有重要医学意义的蛋白质更保守的部分。
