安非他命诱导的多巴胺释放会增加从神经性厌食症中康复的个体的焦虑。
Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa.
机构信息
Department of Psychiatry and Psychotherapy, Division of Biological Psychiatry, Medical University of Vienna, Vienna, Austria.
出版信息
Int J Eat Disord. 2012 Mar;45(2):263-71. doi: 10.1002/eat.20937. Epub 2011 May 3.
Abstract
OBJECTIVE
Genetic, pharmacologic, and physiological data suggest that individuals with anorexia nervosa (AN) have altered striatal dopamine (DA) function.
METHOD
We used an amphetamine challenge and positron emission tomography [(11) C]raclopride paradigm to explore DA striatal transmission in 10 recovered (REC) AN compared with 9 control women (CW).
RESULTS
REC AN and CW were similar for baseline, postamphetamine [(11) C]raclopride binding potential (BP(ND) ) and change (Δ) in BP(ND) for all regions. In CW, ventral striatum Δ BP(ND) was associated with euphoria (r = -0.76; p = 0.03), which was not found for REC AN. Instead, REC AN showed a significant relationship between anxiety and Δ BP(ND) in the precommissural dorsal caudate (r = -0.62, p = 0.05).
DISCUSSION
REC AN have a positive association between endogenous DA release and anxiety in the dorsal caudate. This finding could explain why food-related DA release produces anxiety in AN, whereas feeding is pleasurable in healthy participants.
摘要
目的
遗传、药理学和生理学数据表明，神经性厌食症（AN）患者纹状体多巴胺（DA）功能发生改变。
方法
我们使用安非他命挑战和正电子发射断层扫描[(11)C]raclopride 范式，探究 10 名已康复的 AN 患者（REC AN）和 9 名对照女性（CW）的纹状体 DA 传递。
结果
REC AN 和 CW 在基线、安非他命后[(11)C]raclopride 结合潜能（BP(ND)）以及所有区域的 BP(ND)变化（Δ）方面相似。在 CW 中，腹侧纹状体 Δ BP(ND)与欣快感呈负相关（r = -0.76；p = 0.03），但在 REC AN 中并未发现这种相关性。相反，REC AN 显示前连合背侧尾状核的焦虑与 Δ BP(ND)之间存在显著关系（r = -0.62，p = 0.05）。
讨论
REC AN 的背侧尾状核内内源性 DA 释放与焦虑呈正相关。这一发现可以解释为什么与食物相关的 DA 释放会在 AN 中引起焦虑，而在健康参与者中进食则是愉悦的。
相似文献
1
Amphetamine induced dopamine release increases anxiety in individuals recovered from anorexia nervosa.安非他命诱导的多巴胺释放会增加从神经性厌食症中康复的个体的焦虑。
Int J Eat Disord. 2012 Mar;45(2):263-71. doi: 10.1002/eat.20937. Epub 2011 May 3.
2
Interaction between serotonin transporter and dopamine D2/D3 receptor radioligand measures is associated with harm avoidant symptoms in anorexia and bulimia nervosa.血清素转运体与多巴胺 D2/D3 受体放射性配体相互作用与厌食症和贪食症中的回避伤害症状有关。
Psychiatry Res. 2013 Feb 28;211(2):160-8. doi: 10.1016/j.pscychresns.2012.06.010. Epub 2012 Nov 13.
3
Striatal dopamine release in schizophrenia comorbid with substance dependence.精神分裂症合并物质依赖患者纹状体多巴胺释放。
Mol Psychiatry. 2013 Aug;18(8):909-15. doi: 10.1038/mp.2012.109. Epub 2012 Aug 7.
4
Imaging dopamine transmission in the frontal cortex: a simultaneous microdialysis and [11C]FLB 457 PET study.额叶皮质中多巴胺传递的成像：一项微透析与[11C]FLB 457正电子发射断层扫描同步研究。
Mol Psychiatry. 2014 Mar;19(3):302-10. doi: 10.1038/mp.2013.9. Epub 2013 Feb 26.
5
Dopaminergic activity in Tourette syndrome and obsessive-compulsive disorder.图雷特综合征和强迫症中的多巴胺能活动。
Eur Neuropsychopharmacol. 2013 Nov;23(11):1423-31. doi: 10.1016/j.euroneuro.2013.05.012. Epub 2013 Jul 19.
6
Amphetamine-induced dopamine release in human ventral striatum correlates with euphoria.安非他命引起的人类腹侧纹状体多巴胺释放与欣快感相关。
Biol Psychiatry. 2001 Jan 15;49(2):81-96. doi: 10.1016/s0006-3223(00)01038-6.
7
Striatal dopamine type 2 receptor availability in anorexia nervosa.神经性厌食症中纹状体多巴胺2型受体的可利用性
Psychiatry Res. 2015 Sep 30;233(3):380-7. doi: 10.1016/j.pscychresns.2015.06.013. Epub 2015 Jul 26.
8
Amphetamine-induced striatal dopamine release in schizotypal personality disorder.精神分裂样人格障碍患者中安非他命诱导的纹状体多巴胺释放。
Psychopharmacology (Berl). 2020 Sep;237(9):2649-2659. doi: 10.1007/s00213-020-05561-5. Epub 2020 Jun 22.
9
PET measures of amphetamine-induced dopamine release in ventral versus dorsal striatum.正电子发射断层扫描（PET）对苯丙胺诱导的腹侧与背侧纹状体多巴胺释放的测量。
Neuropsychopharmacology. 1999 Dec;21(6):694-709. doi: 10.1016/S0893-133X(99)00079-2.
10
GBR12909 attenuates amphetamine-induced striatal dopamine release as measured by [(11)C]raclopride continuous infusion PET scans.通过[（11）C]雷氯必利连续输注PET扫描测量发现，GBR12909可减弱苯丙胺诱导的纹状体多巴胺释放。
Synapse. 1999 Sep 15;33(4):268-73. doi: 10.1002/(SICI)1098-2396(19990915)33:4<268::AID-SYN3>3.0.CO;2-W.
引用本文的文献
1
CGRP causes anxiety via HP1γ-KLF11-MAOB pathway and dopamine in the dorsal hippocampus.降钙素基因相关肽通过 HP1γ-KLF11-MAOB 通路和背侧海马中的多巴胺引起焦虑。
Commun Biol. 2024 Mar 19;7(1):322. doi: 10.1038/s42003-024-05937-9.
2
Genetics and neurobiology of eating disorders.进食障碍的遗传学和神经生物学。
Nat Neurosci. 2022 May;25(5):543-554. doi: 10.1038/s41593-022-01071-z. Epub 2022 May 6.
3
Evidence That Methylphenidate Treatment Evokes Anxiety-Like Behavior Through Glucose Hypometabolism and Disruption of the Orbitofrontal Cortex Metabolic Networks.证据表明，哌醋甲酯治疗通过葡萄糖代谢不足和破坏眶额皮质代谢网络引起类似焦虑的行为。
Neurotox Res. 2021 Dec;39(6):1830-1845. doi: 10.1007/s12640-021-00444-9. Epub 2021 Nov 19.
4
Acute Stress Exposure Alters Food-Related Brain Monoaminergic Profiles in a Rat Model of Anorexia.急性应激暴露改变了厌食症大鼠模型中与食物相关的脑单胺能谱。
J Nutr. 2021 Dec 3;151(12):3617-3627. doi: 10.1093/jn/nxab298.
5
Adapting a neuroscience-informed intervention to alter reward mechanisms of anorexia nervosa: a novel direction for future research.采用基于神经科学的干预措施来改变神经性厌食症的奖励机制：未来研究的新方向。
J Eat Disord. 2021 May 26;9(1):63. doi: 10.1186/s40337-021-00417-5.
6
Moving towards specificity: A systematic review of cue features associated with reward and punishment in anorexia nervosa.向特异性迈进：厌食症中与奖励和惩罚相关的线索特征的系统综述。
Clin Psychol Rev. 2020 Jul;79:101872. doi: 10.1016/j.cpr.2020.101872. Epub 2020 May 27.
7
Dopaminergic activity and altered reward modulation in anorexia nervosa-insight from multimodal imaging.神经性厌食症中多巴胺能活动与奖赏调节改变——来自多模态成像的见解
Int J Eat Disord. 2017 May;50(5):593-596. doi: 10.1002/eat.22638. Epub 2016 Oct 18.
8
An investigation of habit learning in Anorexia Nervosa.神经性厌食症中习惯学习的调查。
Psychiatry Res. 2016 Oct 30;244:214-22. doi: 10.1016/j.psychres.2016.07.051. Epub 2016 Jul 26.
9
New Insights in Anorexia Nervosa.神经性厌食症的新见解
Front Neurosci. 2016 Jun 29;10:256. doi: 10.3389/fnins.2016.00256. eCollection 2016.
10
Could dopamine agonists aid in drug development for anorexia nervosa?多巴胺激动剂能否有助于神经性厌食症的药物研发？
Front Nutr. 2014 Nov 3;1:19. doi: 10.3389/fnut.2014.00019. eCollection 2014.
本文引用的文献
1
A comparative evaluation of the dopamine D(2/3) agonist radiotracer [11C](-)-N-propyl-norapomorphine and antagonist [11C]raclopride to measure amphetamine-induced dopamine release in the human striatum.一种多巴胺 D2/3 激动剂放射性示踪剂 [11C](-)-N-丙基-降诺啡烷和拮抗剂 [11C]raclopride 测量安非他命诱导的人纹状体多巴胺释放的比较评价。
J Pharmacol Exp Ther. 2010 May;333(2):533-9. doi: 10.1124/jpet.109.163501. Epub 2010 Jan 26.
2
Positron emission tomography imaging of D(2/3) agonist binding in healthy human subjects with the radiotracer [(11)C]-N-propyl-norapomorphine: preliminary evaluation and reproducibility studies.用放射性示踪剂[(11)C]-N-丙基去甲阿朴吗啡对健康人体受试者中D(2/3)激动剂结合进行正电子发射断层扫描成像：初步评估和重现性研究
Synapse. 2009 Jul;63(7):574-84. doi: 10.1002/syn.20633.
3
Neural correlates of impaired cognitive-behavioral flexibility in anorexia nervosa.神经性厌食症中认知行为灵活性受损的神经关联
Am J Psychiatry. 2009 May;166(5):608-16. doi: 10.1176/appi.ajp.2008.08050775. Epub 2009 Feb 17.
4
Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release.奖励预期期间的中脑边缘功能磁共振成像激活与奖励相关的腹侧纹状体多巴胺释放相关。
J Neurosci. 2008 Dec 24;28(52):14311-9. doi: 10.1523/JNEUROSCI.2058-08.2008.
5
Olanzapine in the treatment of low body weight and obsessive thinking in women with anorexia nervosa: a randomized, double-blind, placebo-controlled trial.奥氮平治疗神经性厌食症女性的低体重和强迫观念：一项随机、双盲、安慰剂对照试验。
Am J Psychiatry. 2008 Oct;165(10):1281-8. doi: 10.1176/appi.ajp.2008.07121900. Epub 2008 Jun 16.
6
Neurobiology of anorexia and bulimia nervosa.神经性厌食症和神经性贪食症的神经生物学
Physiol Behav. 2008 Apr 22;94(1):121-35. doi: 10.1016/j.physbeh.2007.11.037. Epub 2007 Nov 29.
7
Altered reward processing in women recovered from anorexia nervosa.从神经性厌食症中康复的女性的奖赏处理改变。
Am J Psychiatry. 2007 Dec;164(12):1842-9. doi: 10.1176/appi.ajp.2007.07040575.
8
Dopaminergic and glutamatergic regulation of effort- and delay-based decision making.基于努力和延迟的决策的多巴胺能和谷氨酸能调节
Neuropsychopharmacology. 2008 Jul;33(8):1966-79. doi: 10.1038/sj.npp.1301565. Epub 2007 Sep 5.
9
Serotonin transporter binding after recovery from eating disorders.饮食失调康复后的血清素转运体结合情况。
Psychopharmacology (Berl). 2007 Dec;195(3):315-24. doi: 10.1007/s00213-007-0896-7. Epub 2007 Aug 11.
10
Consensus nomenclature for in vivo imaging of reversibly binding radioligands.可逆结合放射性配体体内成像的共识命名法。
J Cereb Blood Flow Metab. 2007 Sep;27(9):1533-9. doi: 10.1038/sj.jcbfm.9600493. Epub 2007 May 9.
Zotero 插件