[Cardiovascular effects of nerve growth factor (analytical literature review) Part I. NGF-indirect intracellular signal pathways].

Traditionally, nerve growth factor (NGF) is considered as chemoattractant that participates in the regulation of cell proliferation, differentiation and myelination of neurons. However, currently available data suggest that the physiological role of NGF in the organism is much wider. This review discusses the features of the influence of NGF on the functional activity of the cardiovascular system, as well as signaling pathways by which activated NGF TrkA and p75(ntr) receptors regulate the functional state of endothelial and vascular smooth muscle cells and cardiomyocytes. In addition, the review observes the theoretical perspectives of agonists and antagonists of TrkA and p75(ntr) receptors for the treatment of various diseases of the heart and blood vessels.