可乐定可消除自发性高血压大鼠对摇晃应激的过度升压反应。

Clonidine abolishes exaggerated pressor responses to shaker stress in spontaneously hypertensive rats.

作者信息

Takeda K, Okajima H, Nakata T, Kawasaki S, Hayashi J, Oguro M, Sasaki S, Nakagawa M

机构信息

Second Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.

出版信息

Am J Hypertens. 1990 Jan;3(1):39-44. doi: 10.1093/ajh/3.1.39.

DOI:10.1093/ajh/3.1.39

PMID:2154239

Abstract

To determine whether clonidine would attenuate exaggerated pressor responses to stress in spontaneously hypertensive rats (SHR), pressor responses to shaker stress were recorded following intracerebroventricular (icv) injections of clonidine in conscious SHR. Pressor responses to shaker stress were significantly larger in SHR than in Wistar-Kyoto rats (WKY). Increased sympathetic nerve responses to shaker stress were also significantly greater in SHR than in WKY. Exaggerated pressor responses in SHR were partly attenuated by adrenalectomy and abolished by clonidine (icv). By contrast, 1-Sar,8-Ile angiotensin II (icv) was ineffective. These findings suggest that in SHR, the alpha-adrenergic system in the brain may contribute to exaggerated pressor responses to shaker stress, but not the brain renin-angiotensin system.

摘要

为了确定可乐定是否会减弱自发性高血压大鼠（SHR）对压力的过度升压反应，在清醒的SHR中进行脑室内（icv）注射可乐定后，记录对摇晃应激的升压反应。SHR对摇晃应激的升压反应显著大于Wistar-Kyoto大鼠（WKY）。SHR对摇晃应激的交感神经反应增强也显著大于WKY。SHR中过度的升压反应部分被肾上腺切除术减弱，并被可乐定（icv）消除。相比之下，1- Sar，8- Ile血管紧张素II（icv）无效。这些发现表明，在SHR中，大脑中的α-肾上腺素能系统可能导致对摇晃应激的过度升压反应，但大脑肾素-血管紧张素系统并非如此。