经皮应用硝酸甘油对改良根治性乳房切除术后皮瓣缺血的预防和愈合是否有效？
Is transdermal nitroglycerin application effective in preventing and healing flap ischaemia after modified radical mastectomy?
作者信息
Kutun Suat, Ay Aybala Agac, Ulucanlar Haluk, Tarcan Oguz, Ay Ahmet, Aldan Mete, Gorkem Guven, Demir Abdullah, Cetin Abdullah
机构信息
Department of General Surgery, Ankara Oncology Research and Training Hospital, Turkey.
出版信息
S Afr J Surg. 2010 Nov;48(4):119-21.
OBJECTIVE
We evaluated the efficacy of local nitroglycerin application in preventing and treating flap complications after modified radical mastectomy in a large patient cohort.
PATIENTS AND METHODS
Between 1993 and 2008, 6426 patients undergoing surgery for stage II breast cancer were enrolled in this prospective study. Patients were randomised into treatment and control groups. In the treatment group a nitroglycerin preparation (Nitroderm) was applied to the flap area. Major complications, recovery periods, menopausal status, additional diseases (diabetes mellitus, hypertension, atherosclerotic heart disease) and adverse effects related to nitroglycerin use were recorded.
RESULTS
The recovery rate without major complications was statistically significantly higher in the nitroglycerin-treated group than in the controls (p < 0.001).
CONCLUSION
Our results indicate that topical nitroglycerin reduces flap complications after breast surgery.
目的
我们在一个大型患者队列中评估了局部应用硝酸甘油在预防和治疗改良根治性乳房切除术后皮瓣并发症方面的疗效。
患者与方法
1993年至2008年期间，6426例接受II期乳腺癌手术的患者纳入了这项前瞻性研究。患者被随机分为治疗组和对照组。治疗组在皮瓣区域应用硝酸甘油制剂（硝酸甘油贴片）。记录主要并发症、恢复期、绝经状态、其他疾病（糖尿病、高血压、动脉粥样硬化性心脏病）以及与使用硝酸甘油相关的不良反应。
结果
硝酸甘油治疗组无主要并发症的恢复率在统计学上显著高于对照组（p < 0.001）。
结论
我们的结果表明，局部应用硝酸甘油可减少乳房手术后的皮瓣并发症。
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