Department of Physiology and Neurobiology, Faculty of Health Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Epilepsia. 2011 May;52 Suppl 3(0 3):33-9. doi: 10.1111/j.1528-1167.2011.03034.x.
Experimental evidence strongly indicates a significant role for inflammatory and immune mediators in initiation of seizures and epileptogenesis. Here we will summarize data supporting the involvement of IL-1β, TNF-α and toll-like receptor 4 in seizure generation and the process of epileptogenesis. The physiological homeostasis and control over brain immune response depends on the integrity of the blood-brain barrier, transforming growth factor (TGF)-β signaling and leukocyte migration. To what extent targeting the immune system is successful in preventing epileptogenesis, and which signaling pathway should be beleaguered is still under intensive research.
实验证据强烈表明，炎症和免疫介质在癫痫发作和癫痫发生的启动中起着重要作用。在这里，我们将总结支持 IL-1β、TNF-α 和 Toll 样受体 4 参与癫痫发作和癫痫发生过程的数据。生理内稳态和对大脑免疫反应的控制依赖于血脑屏障的完整性、转化生长因子 (TGF)-β 信号和白细胞迁移。在多大程度上靶向免疫系统可以成功预防癫痫发生，以及应该针对哪个信号通路进行研究，仍在深入研究中。
