传统DBA/2雄性小鼠感染EMC病毒诱发糖尿病后的肾脏并发症

Kidney complications in EMC virus-induced diabetes in conventional DBA/2 male mice.

作者信息

Shichinohe K, Shimizu M, Ishizaki M, Asakawa M

机构信息

Department of Laboratory Animal Science, Nippon Medical School, Tokyo, Japan.

出版信息

Jikken Dobutsu. 1990 Jan;39(1):113-6. doi: 10.1538/expanim1978.39.1_113.

DOI:10.1538/expanim1978.39.1_113

PMID:2154384

Abstract

Conventional DBA/2 male mice of about 9 weeks of age were inoculated by intraperitoneally injecting EMC virus M variant (10(4) TCID50/0.1 ml/animal) which is passaged in mice. The mice which tested positive for glycosuria and hyperglycemia were examined histopathologically 2 or 5 months after inoculation. The kidneys were examined for thickening of Bowman's capsule and the mesangial matrix. These changes were more clearly observable 5 months after inoculation than they were 2 months after inoculation.

摘要

约9周龄的常规DBA/2雄性小鼠通过腹腔注射在小鼠体内传代的EMC病毒M变异株（10⁴TCID₅₀/0.1 ml/只动物）进行接种。对接种后2个月或5个月时出现糖尿和高血糖检测呈阳性的小鼠进行组织病理学检查。检查肾脏的鲍曼囊和系膜基质增厚情况。接种后5个月比接种后2个月更能清楚地观察到这些变化。