Doi K, Matsuzaki H, Tsuda T, Onodera T
Department of Biomedical Science, Faculty of Agriculture, University of Tokyo, Japan.
Br J Exp Pathol. 1989 Jun;70(3):275-81.
Marked hyperglycaemia and renal lesions developed rapidly in DBA mice infected with 10 plaque-forming units of the D-variant of encephalomyocarditis virus (EMC-D). Renal alterations were demonstrated in the glomeruli, tubular epithelium and small vessels 2 months after infection. Glomerular changes were characterized by mesangial thickening due to an increase of basement membrane-like material in the mesangial matrix. Nodular glomerular lesions were commonly observed 3 months after infection, whereas distinct thickening of the glomerular basement membrane was rarely seen. Besides these glomerular changes, glycogen inclusions in the distal tubular epithelium and medial degeneration in the arterioles were also noticed. The EMC-D-infected DBA mouse appears to be a useful experimental model for the study of human diabetic nephropathy.
感染10个空斑形成单位脑心肌炎病毒D变种（EMC-D）的DBA小鼠迅速出现明显的高血糖症和肾脏病变。感染2个月后，在肾小球、肾小管上皮和小血管中出现了肾脏改变。肾小球变化的特征是系膜增厚，这是由于系膜基质中类似基底膜的物质增加所致。感染3个月后通常观察到结节性肾小球病变，而肾小球基底膜明显增厚则很少见。除了这些肾小球变化外，还注意到远端肾小管上皮中的糖原包涵体和小动脉的中层变性。感染EMC-D的DBA小鼠似乎是研究人类糖尿病肾病的有用实验模型。
