Ward Sara Jane, Rasmussen Bruce A, Corley Gladys, Henry Craig, Kim Jae K, Walker Ellen A, Rawls Scott M
Department of Pharmaceutical Sciences, Temple University Health Sciences Center, Philadelphia, Pennsylvania, USA.
Behav Pharmacol. 2011 Aug;22(4):370-3. doi: 10.1097/FBP.0b013e3283473c10.
No medication is approved to treat cocaine addiction, but mounting evidence suggests that glutamate-directed approaches may reduce cocaine dependence and relapse. We tested the hypotheses that the glutamate transporter subtype 1 activator, ceftriaxone, disrupts acquisition of cocaine self-administration, motivation to self-administer cocaine, and conditioned place preference in mice. Repeated ceftriaxone (200 mg/kg) reduced the ability of mice to acquire cocaine and the motivation to self-administer cocaine after successful acquisition without affecting acquisition of or motivation for sweet food. Repeated ceftriaxone had no effect on cocaine-conditioned place preference. These results suggest that a β-lactam antibiotic reduces the direct reinforcing strength of cocaine without producing nonspecific deficits in conditioned learning processes.
目前尚无药物被批准用于治疗可卡因成瘾，但越来越多的证据表明，针对谷氨酸的治疗方法可能会减轻可卡因依赖和复吸。我们检验了以下假设：谷氨酸转运体1亚型激活剂头孢曲松会破坏小鼠对可卡因自我给药的习得、自我给药可卡因的动机以及条件性位置偏爱。重复给予头孢曲松（200mg/kg）可降低小鼠习得可卡因的能力以及成功习得后自我给药可卡因的动机，且不影响对甜食的习得或动机。重复给予头孢曲松对可卡因条件性位置偏爱没有影响。这些结果表明，一种β-内酰胺类抗生素可降低可卡因的直接强化作用，而不会在条件学习过程中产生非特异性缺陷。
