新型可生物降解的 α-TCP/聚（氨基酸）复合材料人工脊板在脊柱手术后预防椎管内瘢痕粘连。
Novel biodegradable α-TCP/poly(amino acid) composite artificial lamina following spinal surgery for prevention of intraspinal scar adhesion.
机构信息
Department of Orthopaedic Surgery, The Huaxi Hospital, Si-Chuan University, 37 Waiguoxuexiang, Sichuan 610041, China.
出版信息
Eur Spine J. 2011 Dec;20(12):2240-6. doi: 10.1007/s00586-011-1795-5. Epub 2011 May 5.
Biodegradable copolymer α-TCP/poly(amino acid) composite artificial lamina was prepared and used in goat cervical vertebra resection repair. Cervical 4 was removed by laminectomy, and a vertebra defect of 27 × 9 mm was made. α-TCP/poly(amino acid) composite artificial lamina was inserted in the test group. The efficiency of the copolymer during repair and reconstruction of the goats' vertebra was tested by using X-ray, CT scanning, and histological and biomechanical measurements. In the 24 weeks following the operation, the artificial lamina refrained from shifting, and no dural adhesion pressure was observed. In contrast, the control group suffered from infiltration of soft tissue in the spinal canal, dural pressure and α-TCP/poly(amino acid) degradation. In conclusion, α-TCP/poly(amino acid) composite artificial lamina can significantly prevent scar tissue from infiltrating the spinal canal.
可生物降解的 α-TCP/聚（氨基酸）复合材料人工板被制备并用于山羊颈椎切除修复。通过椎板切除术切除颈椎 4，制作 27×9mm 的椎骨缺损。在实验组中插入α-TCP/聚（氨基酸）复合材料人工板。通过 X 射线、CT 扫描以及组织学和生物力学测量来测试共聚物在修复和重建山羊椎体过程中的效果。手术后 24 周，人工板未发生移位，未见硬膜粘连压迫。相比之下，对照组出现椎管内软组织浸润、硬膜压力和α-TCP/聚（氨基酸）降解。综上所述，α-TCP/聚（氨基酸）复合材料人工板可显著防止疤痕组织浸润椎管。
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