Diels A, Pfeifenbring S, Eggers C, Galldiks N, Fink G R, Burghaus L
Klinik und Poliklinik für Neurologie, Uniklinik Köln.
Fortschr Neurol Psychiatr. 2011 May;79(5):298-303. doi: 10.1055/s-0031-1273232. Epub 2011 May 3.
The diagnostic work-up in the case of a suspected cerebral involvement of Whipple's disease involves neuroimaging and analysis of cerebrospinal fluid (CSF) including polymerase chain reaction (PCR) assays for Tropheryma whipplei. As neurological findings may be complex and unspecific, extracerebral symptoms often lead to the suspicion of Whipple's disease. We report the cases of two patients in whom the suspected diagnosis of Whipple's disease could not be proved either by endoscopy or by the analysis of CSF. Only by means of a cerebral biopsy was the diagnosis assumed and specific therapy was initiated.
对于疑似惠普尔病累及脑部的病例，诊断检查包括神经影像学检查和脑脊液（CSF）分析，其中包括针对惠普尔嗜组织菌的聚合酶链反应（PCR）检测。由于神经系统表现可能复杂且不具特异性，脑外症状常常引发对惠普尔病的怀疑。我们报告了两名患者的病例，这两名患者无论是通过内镜检查还是脑脊液分析，均无法证实疑似惠普尔病的诊断。仅通过脑活检才做出诊断并开始进行特异性治疗。
