Tseng Y C, Hyon S H, Ikada Y, Taki W, Uno A, Yonekawa Y
Research Center for Medical Polymers and Biomaterials, Kyoto University, Japan.
J Biomed Mater Res. 1990 Jan;24(1):65-77. doi: 10.1002/jbm.820240107.
Aiming at alleviating the problems of using 2-cyanoacrylates as a material for therapeutic embolization, this experiment made some physical modifications by mixing contrast media. It was found that the physicochemical properties of 2-cyanoacrylates can be altered by changing the concentration and the composition of the contrast media added. A 50 wt% cyanoacrylate-50 wt% contrast medium mixture has enough radiopacity for the practical requirement for embolization. A mixture of 50 wt% (ethoxyethyl cyanoacrylate-5 wt% lactide/epsilon-caprolactone copolymer), 25 wt% lipiodol and 25 wt% tetrafluorodibromoethane provides a viscosity of 13.8 cP, a bonding strength of 14.9 kg/cm2, a set time of 6 s, and a spreading in canine blood of 33 mm. It was concluded that the mixture is much more satisfactory than the conventional cyanoacrylates as an embolus material in vitro. The results obtained by in vivo experiments and clinical trials so far suggest that the mixture is very promising as a material for embolization.
为缓解使用2-氰基丙烯酸酯作为治疗性栓塞材料的问题，本实验通过混合造影剂进行了一些物理改性。研究发现，通过改变添加的造影剂的浓度和组成，可以改变2-氰基丙烯酸酯的物理化学性质。50 wt%氰基丙烯酸酯-50 wt%造影剂混合物具有足够的射线不透性，满足栓塞的实际要求。50 wt%（乙氧基乙基氰基丙烯酸酯-5 wt%丙交酯/ε-己内酯共聚物）、25 wt%碘油和25 wt%四氟二溴乙烷的混合物的粘度为13.8 cP，粘结强度为14.9 kg/cm2，凝固时间为6 s，在犬类血液中的扩散距离为33 mm。得出结论，作为体外栓塞材料，该混合物比传统的氰基丙烯酸酯更令人满意。迄今为止，体内实验和临床试验获得的结果表明，该混合物作为栓塞材料非常有前景。
