Laboratory of Neuropathology and Electron Microscopy, Aristotelian University of Thessaloniki, Thessaloniki, Greece.
Int J Neurosci. 2011 Jul;121(7):347-54. doi: 10.3109/00207454.2011.553753. Epub 2011 May 6.
Alzheimer's disease is a neurodegenerative disorder characterized by progressive decline in memory, loss of professional skills, impairment of judgement and behavior, and decline in social performances. In terms of neuropathology, the morphological hallmarks of the disease are the accumulation of alpha-beta peptide and the neurofibrillary degeneration, associated with synaptic alterations, involving mostly the dendritic spines. This study is based on the morphological analysis of 10 brains, 5 of which were obtained from patients who suffered from Alzheimer's disease and 5 from nondemented senile individuals used as control group. The segments taken in major from the occipital lobe were studied with the use of Golgi method, as well as Gallyas' and Bielschowski' s staining methods. In most of the pyramidal cells in the affected brains, there seems to be important spine loss and extensive dendrite pathology. Apical dendrites are distorted and tortuous. Horizontal dendritic arborization is severely decreased leading to an amputated, bell-shaped cell soma. Senile plaques have been often revealed, and neurofibrillary changes have also been noticed.
阿尔茨海默病是一种神经退行性疾病，其特征是记忆逐渐衰退、丧失专业技能、判断力和行为受损以及社会表现下降。从神经病理学的角度来看，疾病的形态学特征是 α-β 肽的积累和神经纤维变性，伴有突触改变，主要涉及树突棘。本研究基于对 10 个大脑的形态学分析，其中 5 个取自患有阿尔茨海默病的患者，5 个取自无痴呆性衰老个体作为对照组。使用高尔基法以及 Gallyas 和 Bielschowski 染色方法对来自枕叶的主要部分进行研究。在受影响大脑的大多数锥体神经元中，似乎存在重要的棘突丢失和广泛的树突病理学。顶树突扭曲和弯曲。水平树突分支严重减少，导致细胞体呈截断的钟形。经常发现老年斑，也注意到神经纤维变化。
