Department of Dermatology, Osaka City University Graduate School of Medicine, Osaka, Japan.
J Dermatol. 2011 Aug;38(8):798-801. doi: 10.1111/j.1346-8138.2011.01221.x. Epub 2011 May 4.
Vogt-Koyanagi-Harada disease is characterized by marked bilateral uveitis associated with symmetric vitiligo, alopecia, poliosis and dysacousia. Linear immunoglobulin (Ig)A bullous dermatosis (LABD) is characterized by small, tense, subepidermal bullae caused by IgA type autoantibody targeting the basal lamina. LABD patients sometimes show coexistence of IgG type autoantibody, termed linear IgA/IgG bullous dermatosis (LAGBD). We reported a 35-year-old Japanese male case of combined LAGBD and Vogt-Koyanagi-Harada disease. His human leukocyte antigen typing was -A24, B52, C1202, DR1502, DQ*0601. Immunoblot revealed that patient sera reacted to both 180- and 230-kDa proteins at the IgA and IgG level. Because Vogt-Koyanagi-Harada disease and LABD are reported to be associated with other autoimmune diseases, it is probable that Vogt-Koyanagi-Harada disease and LAGBD in our case may be associated with each other in the pathomechanism. However, we cannot exclude the possibility of this being mere coincidence.
Vogt-Koyanagi-Harada 病的特征是明显的双侧葡萄膜炎，伴有对称性白癜风、脱发、白发和感觉神经性耳聋。线性免疫球蛋白（Ig）A 大疱性皮肤病（LABD）的特征是小而紧张的表皮下水疱，由针对基底膜的 IgA 型自身抗体引起。LABD 患者有时会同时出现 IgG 型自身抗体，称为线性 IgA/IgG 大疱性皮肤病（LAGBD）。我们报告了一例 35 岁的日本男性合并 LAGBD 和 Vogt-Koyanagi-Harada 病的病例。他的人类白细胞抗原分型为-A24、B52、C1202、DR1502、DQ*0601。免疫印迹显示患者血清在 IgA 和 IgG 水平上均与 180-和 230-kDa 蛋白反应。由于 Vogt-Koyanagi-Harada 病和 LABD 与其他自身免疫性疾病有关，因此我们的病例中的 Vogt-Koyanagi-Harada 病和 LAGBD 可能在发病机制上相互关联。然而，我们不能排除这种情况纯属巧合的可能性。
