Shahi K S, Bhandari Geeta, Singh Abhishek
Department of Surgery, Radiation and Clinical Oncology, Government Medical College, Haldwani, Nainital, Uttarakhand, India.
J Cancer Res Ther. 2011 Jan-Mar;7(1):19-22. doi: 10.4103/0973-1482.80433.
Estrogen receptor (ER) and progesterone receptor (PR) status has been used since the mid-1970s in the management of breast cancer as an indicator of endocrine responsiveness and as a prognostic factor for early recurrence.
To study the steroid receptor profile and its clinico-pathological correlation in post-menopausal breast cancer patients.
A retrospective and prospective analysis of 80 and 68 patients, respectively, was undertaken to study the prevalence of ER and PR in post-menopausal breast cancer patients. The result of collective observations was analyzed statistically.
In this study, retrospective data on hormonal receptor status of 80 post-menopausal breast cancer patients and prospective data of 68 patients were collected and analyzed.
Student "t" test, Chi-square test.
Receptor positivity was high in higher age group but unlike earlier studies the receptor positivity was lower in incidence. The study showed an incidence of 37.83% receptor positive tumors in post-menopausal women. ER was positive in 27.03% patients of whom 16.2% were also PR positive, while the remaining patients were ER/PR negative. ER was negative in 72.47% patients of whom PR was positive in 10.8% and negative in the remaining. Out of 148 cases, 128 (86.48%) had palpable axillary lymph nodes. Out of 148 patients, 36 (24.34%) had supraclavicular lymph node involvement (Chi-square = 1.70, P = 0.193). Out of 148 cases, 144 (92.29%) were infiltration ductal carcinomas. Grade I tumors were more common in receptor positive tumors while grade II and III tumors were more common in receptor negative tumors. Receptor negative tumors were more aggressive in terms of peau de' orange, ulceration, fungation and chest wall invasion. Metastases and axillary lymph node involvement was observed more in receptor negative tumors; however, supraclavicular lymph node involvement was equal in both the groups. Infiltrating ductal carcinoma was the most common type of carcinoma in both the groups.
The receptor positivity of steroid receptors was more in higher age groups, but the incidence of receptor positivity was lower than that reported in earlier studies. No statistically significant association was found between receptor status and clinical presentation of breast cancer, histopathological status of tumor and metastases.
自20世纪70年代中期以来，雌激素受体（ER）和孕激素受体（PR）状态已被用于乳腺癌的治疗，作为内分泌反应性的指标和早期复发的预后因素。
研究绝经后乳腺癌患者的类固醇受体谱及其临床病理相关性。
分别对80例和68例患者进行回顾性和前瞻性分析，以研究绝经后乳腺癌患者中ER和PR的患病率。对集体观察结果进行统计学分析。
本研究收集并分析了80例绝经后乳腺癌患者的激素受体状态回顾性数据和68例患者的前瞻性数据。
学生“t”检验、卡方检验。
较高年龄组的受体阳性率较高，但与早期研究不同的是，受体阳性率的发病率较低。该研究显示绝经后女性中受体阳性肿瘤的发病率为37.83%。27.03%的患者ER阳性，其中16.2%的患者PR也阳性，其余患者ER/PR阴性。72.47%的患者ER阴性，其中10.8%的患者PR阳性，其余患者PR阴性。在148例病例中，128例（86.48%）可触及腋窝淋巴结。在148例患者中，36例（24.34%）有锁骨上淋巴结受累（卡方=1.70，P=0.193）。在148例病例中，144例（92.29%）为浸润性导管癌。I级肿瘤在受体阳性肿瘤中更常见，而II级和III级肿瘤在受体阴性肿瘤中更常见。受体阴性肿瘤在橘皮样改变、溃疡、糜烂和胸壁侵犯方面更具侵袭性。受体阴性肿瘤中观察到转移和腋窝淋巴结受累更多；然而，两组锁骨上淋巴结受累情况相同。浸润性导管癌是两组中最常见的癌类型。
类固醇受体的受体阳性率在较高年龄组中更高，但受体阳性率的发病率低于早期研究报道。未发现受体状态与乳腺癌临床表现、肿瘤组织病理学状态和转移之间存在统计学显著关联。
