PCR Center, Faculty of Biology, University of Belgrade, Belgrade, Serbia.
Neuroepidemiology. 2011;36(3):177-82. doi: 10.1159/000327029. Epub 2011 May 5.
The aim of this study was to determine prevalence and 15-year survival in Charcot-Marie-Tooth disease (CMT).
The study covers the period from 1 January 1988 to 31 December 2007 in the territory of Belgrade. Data on a number of CMT-affected persons and their basic demographic characteristics as well as data on the disease were collected from medical records. Data on the course and outcome of the disease were obtained through direct contact with patients, their families and their physicians.
We registered 161 patients with CMT in the population of Belgrade. The most frequent type was CMT1. The crude prevalence of CMT disease in the Belgrade population on 31 December 2007 was 9.7/100,000 for all subtypes, 7.1/100,000 for CMT1, and 2.3/100,000 for CMT2. Gender-specific prevalence was 11.2/100,000 for males and 8.3/100,000 for females. The highest age-specific prevalence was registered in the oldest age group (75+ years; 19.1/100,000), and the lowest one in patients aged 5-14 years (5.0/100,000). The cumulative probability of 15-year survival for CMT patients in Belgrade was 85.6 ± 7.8% (44.9 ± 31.8% for males and 98.2 ± 1.8% for females).
The prevalence of CMT found in Belgrade is similar to the prevalence registered in Southern European countries.
本研究旨在确定 Charcot-Marie-Tooth 病（CMT）的患病率和 15 年生存率。
本研究涵盖了 1988 年 1 月 1 日至 2007 年 12 月 31 日期间贝尔格莱德的地域情况。从病历中收集了受 CMT 影响的人数及其基本人口统计学特征以及有关疾病的数据。通过与患者、其家人和医生直接联系，获得了有关疾病过程和结果的数据。
我们在贝尔格莱德人群中登记了 161 例 CMT 患者。最常见的类型是 CMT1。2007 年 12 月 31 日，贝尔格莱德人群中所有 CMT 亚型的粗患病率为 9.7/100,000，CMT1 为 7.1/100,000，CMT2 为 2.3/100,000。男性患病率为 11.2/100,000，女性为 8.3/100,000。年龄特异性患病率最高的是最年长的年龄组（75 岁以上；19.1/100,000），最低的是 5-14 岁的患者（5.0/100,000）。贝尔格莱德 CMT 患者 15 年的累积生存率为 85.6 ± 7.8%（男性为 44.9 ± 31.8%，女性为 98.2 ± 1.8%）。
贝尔格莱德发现的 CMT 患病率与南欧国家登记的患病率相似。
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