Clinic of Neurology, Clinical Center Kragujevac, Faculty of Medicine, University of Kragujevac, Kragujevac, Serbia.
Neuroepidemiology. 2011;37(2):102-6. doi: 10.1159/000330836. Epub 2011 Sep 15.
The aim of this study was to estimate the prevalence of multiple sclerosis (MS) in the district of Sumadija (central part of Serbia).
All persons suffering from MS, with permanent residence in the region, were recruited. Prevalence was calculated on December 31, 2006, according to a standard procedure.
On December 31, 2006, one hundred ninety-four patients (72 males and 122 females) were found to have MS. We found a crude MS prevalence of 64.9/100,000 (49.3/100,000 for males and 79.9/ 100,000 for females). The highest prevalence rates were registered in the age group of 30-39 years for females and 40-49 years for males, although the age-specific rates were higher in females in all age groups. The mean age at onset was 34.2 ± 9.3 years. The average duration of MS was 8.9 ± 6.2 years. The median EDSS score was 3.9 ± 2.0. The course of MS was relapsing-remitting in 63.9% of patients, secondary progressive in 32.5%, and primary progressive in 3.6%. At MS onset, motor symptoms were present in 70.1% of patients, sensory in 40.7%, cerebellar in 21.1%, brainstem in 15.5%, visual in 22.2%, and bowel/bladder disturbances in 22.2%.
Our results demonstrate that the MS prevalence registered in the Serbian district Sumadija is similar to that of other surrounding areas in Southeastern Europe.
本研究旨在评估塞尔维亚中部苏马迪加地区多发性硬化症（MS）的患病率。
招募所有在该地区有常住居民身份且患有 MS 的人。患病率是根据标准程序于 2006 年 12 月 31 日计算的。
截至 2006 年 12 月 31 日，共发现 194 名患者（72 名男性和 122 名女性）患有 MS。我们发现 MS 的粗患病率为 64.9/100,000（男性为 49.3/100,000，女性为 79.9/100,000）。女性的患病率在 30-39 岁年龄组和男性的 40-49 岁年龄组最高，但在所有年龄组中，女性的年龄特异性患病率更高。发病平均年龄为 34.2 ± 9.3 岁。MS 的平均病程为 8.9 ± 6.2 年。平均 EDSS 评分为 3.9 ± 2.0。MS 的病程在 63.9%的患者中为复发缓解型，在 32.5%的患者中为继发进展型，在 3.6%的患者中为原发进展型。在 MS 发病时，70.1%的患者有运动症状，40.7%的患者有感觉症状，21.1%的患者有小脑症状，15.5%的患者有脑干症状，22.2%的患者有视觉症状，22.2%的患者有肠/膀胱功能障碍。
我们的结果表明，塞尔维亚苏马迪加地区登记的 MS 患病率与东南欧其他周边地区相似。
