Instituto Nacional de Câncer, Ministério da Saúde, Rio de Janeiro, Brazil.
Int J Gynecol Cancer. 2011 May;21(4):706-10. doi: 10.1111/IGC.0b013e3181f87d69.
The purpose of this study was to evaluate the effect of thromboembolic event (TEE) on the prognosis and survival of women diagnosed with the International Federation of Gynecology and Obstetrics (FIGO) stage IIIB cervical cancer undergoing treatment at the National Cancer Institute (Instituto Nacional de Câncer [INCA], Ministério da Saúde), Brazil.
A total of 1020 women with FIGO stage IIIB cervical cancer (International Classification of Diseases, C53.9), who had received treatment at this institute between 2000 and 2004, were identified. Data were obtained from the hospital cancer registry at INCA. Patients were followed up from the date of their diagnosis of cervical cancer at INCA until their death or last follow-up visit. The date of TEE diagnosis was defined as the date of one of the following tests diagnosing this condition: Doppler ultrasound scan, computed tomography scan, or in 1 single case echocardiography. The Kaplan-Meyer method was used to perform long-term survival analysis.
The presence of TEE in patients with FIGO stage IIIB cervical cancer seems to be indicative of the severity of the disease and poorer prognosis. The most important finding is that in the patients who developed TEE, this complication occurred around the time of diagnosis of progression of the disease. Disease progression may have been the triggering factor for the development of TEE.
本研究旨在评估血栓栓塞事件（TEE）对在巴西国家癌症研究所（INCA，卫生部）接受治疗的国际妇产科联合会（FIGO）分期为 IIIB 期宫颈癌女性的预后和生存的影响。
共确定了 1020 名在该研究所接受治疗的 FIGO 分期为 IIIB 期宫颈癌（国际疾病分类，C53.9）的女性。数据来自 INCA 医院癌症登记处。患者从 INCA 诊断为宫颈癌之日起接受随访，直至死亡或最后一次随访。TEE 诊断日期定义为以下诊断该疾病的检查之一的日期：多普勒超声扫描、计算机断层扫描或在 1 个病例中超声心动图。采用 Kaplan-Meier 方法进行长期生存分析。
FIGO 分期为 IIIB 期宫颈癌患者存在 TEE 似乎表明疾病严重程度和预后较差。最重要的发现是，在发生 TEE 的患者中，这种并发症发生在疾病进展诊断的时间左右。疾病进展可能是 TEE 发展的触发因素。
