Oral Health Science Center hrc7, Tokyo Dental College, Mihama-ku, Chiba, Japan.
Hum Cell. 2011 Mar;24(1):30-4. doi: 10.1007/s13577-011-0008-1. Epub 2011 Feb 22.
Fibroblasts exist in the interstices of various organs as a component of connective tissue and are one of several types of somatic cells that have been well established in culture. They have been reported to undergo myogenic conversion and to induce the expression of genes associated with pluripotency. However, their own plasticity with regard to direct differentiation has scarcely been described. Here, we show that human fibroblasts are able to differentiate directly to all three germ layer derivatives. The results indicate that human dermal fibroblasts have more plasticity than has been generally thought and that fibroblasts have potential utility as a source for cell therapy.
成纤维细胞作为结缔组织的一个组成部分存在于各种器官的间隙中，是已经在培养中得到很好确立的几种体细胞之一。据报道，它们可以进行肌生成转化，并诱导与多能性相关基因的表达。然而，关于其直接分化的自身可塑性几乎没有被描述。在这里，我们表明人类成纤维细胞能够直接分化为所有三个胚层的衍生物。结果表明，人类真皮成纤维细胞比人们普遍认为的具有更大的可塑性，并且成纤维细胞作为细胞治疗的来源具有潜在的用途。
