Department of Dermatology, Faculty of Medicine, University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan.
Mod Rheumatol. 2011 Oct;21(5):548-52. doi: 10.1007/s10165-011-0436-5. Epub 2011 Mar 10.
Systemic sclerosis (SSc) is characterized by vascular injuries, and bosentan has recently been proved to be efficacious for the prevention of new digital ulcers in SSc. We herein report a case of SSc in a patient with refractory digital ulcers and gangrene treated with bosentan. Stenosis of the ulnar artery, evaluated by magnetic resonance angiography, was attenuated by the bosentan treatment, suggesting that bosentan exerts a reverse remodeling effect against the pathological organic changes of arteries in SSc.
系统性硬化症（SSc）的特征是血管损伤，波生坦最近已被证明可有效预防 SSc 中新发的手指溃疡。我们在此报告一例使用波生坦治疗难治性手指溃疡和坏疽的 SSc 患者。磁共振血管造影评估发现，尺动脉狭窄得到了波生坦治疗的缓解，这表明波生坦对 SSc 中动脉的病理性组织改变具有逆转重构作用。
