Mooney P A, Walters J M, Little M P, Stevens F M, McCarthy C F
Digestion. 1978;18(1-2):6-15. doi: 10.1159/000198179.
A correlation was sought between changes in enzymes involved in gastric acid secretion (Mg-, NaK-, K- and HCO3-stimulated ATPases) and histological changes in gastric biopsies. Alkaline phosphatase was also studied. Mg- and NaK-stimulated ATPase activities increased significantly in biopsies from the pylorus and antrum which showed moderate or severe gastritis. NaK ATPase levels increased and HCO3 ATPase decreased in incisural, body and fundic mucosa which had intestinal metaplasia and atrophic gastritis. No K+ ATPase was found in normal mucosa. The total activity of alkaline phosphatase did not vary with histological changes in the gastric mucosa. Results indicate that the ATPase enzyme systems are sensitive indicators of gastric mucosal disease.
研究了胃酸分泌相关酶（镁、钠钾、钾和碳酸氢根刺激的ATP酶）的变化与胃活检组织学变化之间的相关性。同时也对碱性磷酸酶进行了研究。在显示中度或重度胃炎的幽门和胃窦活检组织中，镁和钠钾刺激的ATP酶活性显著增加。在有肠化生和萎缩性胃炎的贲门、胃体和胃底黏膜中，钠钾ATP酶水平升高而碳酸氢根ATP酶水平降低。在正常黏膜中未发现钾离子ATP酶。碱性磷酸酶的总活性并未随胃黏膜的组织学变化而改变。结果表明，ATP酶系统是胃黏膜疾病的敏感指标。
