Mittal K, Neri A, Feiner H, Schinella R, Alfonso F
Department of Pathology, New York University School of Medicine, Bellevue Hospital, NY 10016.
Cancer. 1990 Mar 15;65(6):1345-9. doi: 10.1002/1097-0142(19900315)65:6<1345::aid-cncr2820650616>3.0.co;2-8.
A case of lymphomatoid granulomatosis of lung that occurred in a patient with the acquired immunodeficiency syndrome (AIDS) was studied by light microscope, electron microscope, cell surface markers, and Southern blot test. Clonal selection of two clones of B-cells was seen. Two clones were infected with Epstein-Barr virus. There was no c-myc rearrangement. Lymphomatoid granulomatosis in patients with AIDS may represent multiclonal selection of B-lymphocytes in association with Epstein-Barr virus infection.
对一名获得性免疫缺陷综合征（艾滋病）患者发生的肺淋巴瘤样肉芽肿病病例进行了光镜、电镜、细胞表面标志物及Southern印迹试验研究。观察到两个B细胞克隆的克隆选择。两个克隆均感染了爱泼斯坦-巴尔病毒。未发现c-myc重排。艾滋病患者的淋巴瘤样肉芽肿病可能代表与爱泼斯坦-巴尔病毒感染相关的B淋巴细胞多克隆选择。
