Wu Katie Pei-Hsuan, Ke Jyh-Yuh, Chen Chung-Yao, Chen Chia-Ling, Chou Ming-Yen, Pei Yu-Cheng
Department of Physical Medicine and Rehabilitation, Chang Gung Memorial Hospital, Taoyuan, Taiwan.
J Child Neurol. 2011 Jul;26(7):838-43. doi: 10.1177/0883073810395391. Epub 2011 May 6.
Intrasalivary gland injection of botulinum toxin type A is known to treat sialorrhea effectively in children with cerebral palsy. However, oral health may be compromised with escalating dose. In this randomized, double-blind, and placebo-controlled pilot trial, the authors aim to determine the therapeutic effect of low-dose, ultrasonography-controlled botulinum toxin type A injection to bilateral parotid and submandibular glands on oral health in the management of sialorrhea. Twenty children diagnosed with cerebral palsy were randomly assigned to 2 groups. The treatment group received botulinum toxin type A injections, whereas the control received normal saline in the same locations. The authors evaluated subjective drooling scales, salivary flow rate, and oral health (salivary compositions and cariogenic bacterial counts). A significant decrease was found in salivary flow rate at the 1- and 3-month follow-up in the botulinum toxin-treated group. The authors suggest that current protocol can effectively manage sialorrhea while maintaining oral health.
已知经唾液腺内注射A型肉毒杆菌毒素可有效治疗脑瘫患儿的流涎症。然而，随着剂量增加，口腔健康可能会受到影响。在这项随机、双盲、安慰剂对照的试验中，作者旨在确定在超声控制下向双侧腮腺和颌下腺注射低剂量A型肉毒杆菌毒素对治疗流涎症时口腔健康的治疗效果。20名被诊断为脑瘫的儿童被随机分为两组。治疗组接受A型肉毒杆菌毒素注射，而对照组在相同部位注射生理盐水。作者评估了主观流涎量表、唾液流速和口腔健康（唾液成分和致龋菌计数）。在接受肉毒杆菌毒素治疗的组中，1个月和3个月随访时唾液流速显著降低。作者认为，当前方案可在维持口腔健康的同时有效治疗流涎症。
