Department of Anatomy, Karolinska Institutet, Stockholm (Sweden) Department of Hand Surgery, Sabbatsbergs Hospital, Stockholm (Sweden).
Restor Neurol Neurosci. 1991 Jan 1;3(4):205-9. doi: 10.3233/RNN-1991-3405.
After dorsal root ganglionectomy in adult rats, the dorsal root was cut close to the spinal cord and implanted into the dorsal horn. Outgrowth from neurons in he dorsal horn of the spinal cord into the implanted dorsal root could be demonstrated after 3 months by means of retrograde HRP labeling. Double-labeling experiments showed that some of these neurons had retained their central projections while extending new processes into the implanted root. The possibility to reconstruct the sensory pathway by replacing the damaged primary sensory neuron with peripheral outgrowth from secondary sensory neurons is discussed.
在成年大鼠进行背根神经节切除术后，将靠近脊髓的背根切断并植入背角。通过逆行 HRP 标记，可在 3 个月后证明脊髓背角中的神经元向植入的背根中生长。双标记实验表明，其中一些神经元在向植入的根中延伸新的突起的同时保留了其中枢投射。讨论了通过用二级感觉神经元的外周生长来替代受损的初级感觉神经元来重建感觉通路的可能性。
