心得安对去甲丙咪嗪诱导的大鼠脑内去甲肾上腺素能轴突再生的影响。
The effect of propranolol on the desipramine-induced regeneration of brain noradrenergic axons in the rat.
机构信息
Department of Physiology, Faculty of Medicine, Kanazawa University, Kanazawa 920, Japan.
出版信息
Restor Neurol Neurosci. 1994 Jan 1;6(4):297-300. doi: 10.3233/RNN-1994-6405.
The antagonizing effect of the β-adrenoceptor antagonist propranolol (PRP) on the desipramine (DMI)-induced regeneration of brain noradrenergic fibers was examined. The symmetrical sites of the rat frontal cortex were pretreated with 6-hydroxydopamine (6-OHDA). Then, the same cortical site of one hemisphere was infused with DMI, while the corresponding site of the other hemisphere was infused with DMI (1 mM) plus PRP (1 mM). The DMI-induced axonal regeneration was attenuated by PRP. This finding suggests that activation of β-adrenoceptors is involved at least in part in the regeneration of brain noradrenergic axons.
β-肾上腺素受体拮抗剂心得安（PRP）对去甲肾上腺素能纤维的再生具有拮抗作用，本研究对此进行了探讨。预先用 6-羟多巴胺（6-OHDA）处理大鼠前额叶皮质的对称部位，然后用 DMI 对一侧大脑皮质的相同部位进行输注，对侧大脑皮质的相同部位则用 DMI（1mM）加 PRP（1mM）进行输注。PRP 可减弱 DMI 诱导的轴突再生。这一发现表明，β-肾上腺素受体的激活至少部分参与了脑去甲肾上腺素能轴突的再生。
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