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Mathematical and experimental approaches to identify and predict the effects of chemotherapy on neuroglial precursors.数学和实验方法,用于识别和预测化疗对神经胶质前体细胞的影响。
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A composite likelihood approach to the analysis of longitudinal clonal data on multitype cellular systems under an age-dependent branching process.基于年龄相关分支过程的多类型细胞系统纵向克隆数据分析的复合似然方法。
Biostatistics. 2011 Jan;12(1):173-91. doi: 10.1093/biostatistics/kxq050. Epub 2010 Aug 23.
3
An age-dependent branching process model for the analysis of CFSE-labeling experiments.用于分析 CFSE 标记实验的与年龄相关的分支过程模型。
Biol Direct. 2010 Jun 22;5:41. doi: 10.1186/1745-6150-5-41.
4
Saddlepoint approximations to the moments of multitype age-dependent branching processes, with applications.多类型年龄依赖分支过程矩的鞍点近似及其应用
Biometrics. 2010 Jun;66(2):567-77. doi: 10.1111/j.1541-0420.2009.01281.x. Epub 2009 Jun 9.
5
Stochastic modeling of oligodendrocyte generation in cell culture: model validation with time-lapse data.细胞培养中少突胶质细胞生成的随机建模:用延时数据进行模型验证
Theor Biol Med Model. 2006 May 17;3:21. doi: 10.1186/1742-4682-3-21.
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Estimating the life-span of oligodendrocytes from clonal data on their development in cell culture.根据少突胶质细胞在细胞培养中的克隆发育数据估算其寿命。
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A stochastic model to analyze clonal data on multi-type cell populations.一种用于分析多类型细胞群体克隆数据的随机模型。
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An alternative stochastic model of generation of oligodendrocytes in cell culture.细胞培养中少突胶质细胞生成的另一种随机模型。
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Estimation problems associated with stochastic modeling of proliferation and differentiation of O-2A progenitor cells in vitro.体外少突胶质前体细胞增殖与分化随机建模相关的估计问题。
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A random walk model of oligodendrocyte generation in vitro and associated estimation problems.体外少突胶质细胞生成的随机游走模型及相关估计问题。
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离散观测连续时间马尔可夫分支过程的拟极大似然估计和伪极大似然估计。

Quasi- and pseudo-maximum likelihood estimators for discretely observed continuous-time Markov branching processes.

作者信息

Chen Rui, Hyrien Ollivier

机构信息

Department of Biostatistics and Computational Biology, University of Rochester Medical Center.

出版信息

J Stat Plan Inference. 2011 Jul 1;141(7):2209-2227. doi: 10.1016/j.jspi.2011.01.016.

DOI:10.1016/j.jspi.2011.01.016
PMID:21552356
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3086408/
Abstract

This article deals with quasi- and pseudo-likelihood estimation in a class of continuous-time multi-type Markov branching processes observed at discrete points in time. "Conventional" and conditional estimation are discussed for both approaches. We compare their properties and identify situations where they lead to asymptotically equivalent estimators. Both approaches possess robustness properties, and coincide with maximum likelihood estimation in some cases. Quasi-likelihood functions involving only linear combinations of the data may be unable to estimate all model parameters. Remedial measures exist, including the resort either to non-linear functions of the data or to conditioning the moments on appropriate sigma-algebras. The method of pseudo-likelihood may also resolve this issue. We investigate the properties of these approaches in three examples: the pure birth process, the linear birth-and-death process, and a two-type process that generalizes the previous two examples. Simulations studies are conducted to evaluate performance in finite samples.

摘要

本文探讨了在离散时间点观测的一类连续时间多类型马尔可夫分支过程中的拟似然估计和伪似然估计。针对这两种方法,讨论了“常规”估计和条件估计。我们比较了它们的性质,并确定了它们导致渐近等价估计量的情形。这两种方法都具有稳健性,并且在某些情况下与最大似然估计一致。仅涉及数据线性组合的拟似然函数可能无法估计所有模型参数。存在补救措施,包括采用数据的非线性函数或对适当的σ-代数上的矩进行条件设定。伪似然方法也可以解决这个问题。我们在三个例子中研究了这些方法的性质:纯生过程、线性生死过程以及一个推广了前两个例子的两类型过程。进行了模拟研究以评估有限样本中的性能。