Oncu Kemal, Yazgan Yusuf, Kaplan Mustafa, Tanoglu Alpaslan, Kucuk Irfan, Berber Ufuk, Demirturk Levent
Gastroenterology Department, GATA Haydarpasa Training Hospital, Istanbul, Turkey.
Case Rep Gastroenterol. 2011 Apr 12;5(1):139-43. doi: 10.1159/000326927.
We report the case of a 24-year-old male patient admitted for recent ascites and splenomegaly of unknown origin. The patient was referred to our institution with complaints of diarrhea, epigastric pain, abdominal cramping and weight loss over the past three weeks. The acute onset presented with colicky abdominal pain and peritoneal effusion. History revealed reduced appetite and weight gain of 7 kg over the last one month. His past medical history and family history was negative. He had no history of alcohol abuse or viral hepatitis infection. Laboratory data revealed normal transaminases and bilirubin levels, and alkaline phosphatase and gammaglutamyltransferase were within normal range. A diagnostic laparoscopy was performed which showed free peritoneal fluid and normal abdominal viscera. Upper gastrointestinal system endoscopy performed a few days later revealed diffuse severe erythematous pangastritis and gastroduodenal gastric reflux. Duodenal biopsies showed chronic nonspecific duodenitis. Antrum and corpus biopsies showed chronic gastritis. The ascitic fluid was straw-colored and sterile with 80% eosinophils. Stool exam was negative for parasitic infection. Treatment with albendazole 400 mg twice daily for 5 days led to the disappearance of ascites and other signs and symptoms. Three months after albendazole treatment the eosinophilic cell count was normal. The final diagnosis was consistent with parasitic infection while the clinical, sonographic and histological findings suggested an eosinophilic ascites. We emphasize the importance of excluding parasitic infection in all patients with eosinophilic ascites. We chose an alternative way (albendazole treatment) to resolve this clinical picture. With our alternative way for excluding this parasitic infection, we treated the patient and then found the cause.
我们报告了一例24岁男性患者,因近期不明原因的腹水和脾肿大入院。该患者因过去三周出现腹泻、上腹部疼痛、腹部绞痛和体重减轻等症状被转诊至我院。急性起病表现为绞痛性腹痛和腹腔积液。病史显示食欲减退,过去一个月体重增加了7公斤。他的既往病史和家族史均为阴性。他无酗酒或病毒性肝炎感染史。实验室数据显示转氨酶和胆红素水平正常,碱性磷酸酶和γ-谷氨酰转移酶在正常范围内。进行了诊断性腹腔镜检查,显示有游离腹腔积液且腹部脏器正常。几天后进行的上消化道系统内镜检查显示弥漫性重度红斑性全胃炎和胃十二指肠胃反流。十二指肠活检显示慢性非特异性十二指肠炎。胃窦和胃体活检显示慢性胃炎。腹水呈草黄色且无菌,嗜酸性粒细胞占80%。粪便检查未发现寄生虫感染。给予阿苯达唑400毫克,每日两次,共5天,腹水及其他体征和症状消失。阿苯达唑治疗三个月后嗜酸性粒细胞计数恢复正常。最终诊断为寄生虫感染,而临床、超声和组织学检查结果提示为嗜酸性腹水。我们强调在所有嗜酸性腹水患者中排除寄生虫感染的重要性。我们选择了一种替代方法(阿苯达唑治疗)来解决这一临床情况。通过我们排除这种寄生虫感染的替代方法,我们对患者进行了治疗,然后找到了病因。