Pinte Larisa, Baicuş Cristian
Internal Medicine Department, "Colentina" Clinical Hospital, Bucharest, Romania.
"Carol Davila" School of Medicine, Bucharest, Romania.
Rom J Intern Med. 2019 Jun 1;57(2):110-124. doi: 10.2478/rjim-2018-0041.
In the last years an uprising interest for a relatively unknown entity, eosinophilic ascites (EA), has been recorded. Our aim is to investigate the potential causes of EA development, as well as clinical, laboratory, endoscopic and radiologic features, management and outcome in these patients.
The following research was performed on PubMed (MEDLINE) database using the medical subject headings [Mesh] terms "Ascites" AND "Eosinophils".
A total of 284 results, dating from 1962 onwards, were found and abstracts were examined. 131 papers were excluded and the remaining 153 publications, consisting in case reports and series of cases, were analyzed. From 171 patients with EA, 127 subjects (74%) had EGE, 17 (10%) parasitic and fungal infections, 11(7%) Hypereosinophilic syndrome and 16 patients (9%) less common diseases (eosinophilic pancreatitis, chronic eosinophilic leukemia, myelofibrosis, T-cell lymphoma, Churg Strauss Syndrome, Systemic lupus erythematosus, Familial paroxysmal polyserositis and Ménétrier's disease). High eosinophil blood count and IgE levels as well as gastrointestinal symptoms are frequent. The diagnosis is based on ascitic fluid analysis, imaging and endoscopic biopsies. Therapy with corticosteroids results in resolution of eosinophilic ascites in almost all patients.
In most cases, in the absence of allergy, parasitic infections, malignancy, hematological disorders, peritoneal tuberculosis, inflammatory bowel disease or autoimmune disease, EA develops as a manifestation of eosinophilic gastroenteritis.
在过去几年中，人们对一个相对不太知名的实体——嗜酸性腹水（EA）的兴趣日益增加。我们的目的是研究EA发生的潜在原因，以及这些患者的临床、实验室、内镜和放射学特征、管理和结局。
在PubMed（MEDLINE）数据库中使用医学主题词[Mesh]术语“Ascites”（腹水）和“Eosinophils”（嗜酸性粒细胞）进行了以下研究。
共找到1962年以来的284条结果，并对摘要进行了审查。排除了131篇论文，对其余153篇包括病例报告和病例系列的出版物进行了分析。在171例EA患者中，127例（74%）患有嗜酸性胃肠炎（EGE），17例（10%）患有寄生虫和真菌感染，11例（7%）患有高嗜酸性粒细胞综合征，16例（9%）患有罕见疾病（嗜酸性胰腺炎、慢性嗜酸性粒细胞白血病、骨髓纤维化、T细胞淋巴瘤、变应性肉芽肿性血管炎、系统性红斑狼疮、家族性阵发性多浆膜炎和门脉高压性胃病）。高嗜酸性粒细胞血症和IgE水平以及胃肠道症状很常见。诊断基于腹水分析、影像学和内镜活检。几乎所有患者使用皮质类固醇治疗后嗜酸性腹水均可消退。
在大多数情况下，在没有过敏、寄生虫感染、恶性肿瘤、血液系统疾病、腹膜结核、炎症性肠病或自身免疫性疾病的情况下，EA作为嗜酸性胃肠炎的一种表现而发生。
