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医疗旅游的风险:携带 NDM-1 耐药基因的大肠杆菌导致一名医疗游客发热性中性粒细胞减少症。

The perils of medical tourism: NDM-1-positive Escherichia coli causing febrile neutropenia in a medical tourist.

机构信息

Department of Haematology-Oncology, National Univeristy Hospital, 1E Lower Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228.

出版信息

Singapore Med J. 2011 Apr;52(4):299-302.

Abstract

NDM-1 is a new metallo-beta-lactamase that readily hydrolyses carbapenems, penicillins and cephalosporins. Its rising incidence has been reported in many countries around the world, with many cases linked to a possible origin from the Indian subcontinent. Due to the lack of effective antibiotic regimes to treat these infections, the increased prevalence of NDM-1 is alarming. We describe a case of NDM-1 infection in an immunocompromised foreign patient, and discuss its implications.

摘要

NDM-1 是一种新型的金属β-内酰胺酶,能够轻易地水解碳青霉烯类、青霉素类和头孢菌素类抗生素。这种酶在世界各地的许多国家都有出现,且有许多案例都可能与印度次大陆有关。由于缺乏有效的抗生素治疗方案,这种酶的广泛传播令人担忧。我们报告了一例免疫功能低下的外国患者感染 NDM-1 的病例,并对其进行了讨论。

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