Department of Haematology-Oncology, National Univeristy Hospital, 1E Lower Kent Ridge Road, NUHS Tower Block Level 7, Singapore 119228.
Singapore Med J. 2011 Apr;52(4):299-302.
NDM-1 is a new metallo-beta-lactamase that readily hydrolyses carbapenems, penicillins and cephalosporins. Its rising incidence has been reported in many countries around the world, with many cases linked to a possible origin from the Indian subcontinent. Due to the lack of effective antibiotic regimes to treat these infections, the increased prevalence of NDM-1 is alarming. We describe a case of NDM-1 infection in an immunocompromised foreign patient, and discuss its implications.
NDM-1 是一种新型的金属β-内酰胺酶，能够轻易地水解碳青霉烯类、青霉素类和头孢菌素类抗生素。这种酶在世界各地的许多国家都有出现，且有许多案例都可能与印度次大陆有关。由于缺乏有效的抗生素治疗方案，这种酶的广泛传播令人担忧。我们报告了一例免疫功能低下的外国患者感染 NDM-1 的病例，并对其进行了讨论。
