DE A, Boyadjieva N, Pastorcic M, Sarkar D
WASHINGTON STATE UNIV, DEPT VET & COMPARAT ANAT PHARMACOL & PHYSIOL, PULLMAN, WA 99164 USA.
Int J Oncol. 1995 Sep;7(3):643-8. doi: 10.3892/ijo.7.3.643.
The effect of alcohol on estrogen-regulated lactotropic cell proliferation was examined in Fisher 344 rats. Alcohol was administered for 2 weeks using liquid diet containing 8.7% ethanol (v/v) and 37% ethanol-derived calories. The control group was pair-fed with an isocaloric diet minus the ethanol or adlib-fed with normal diet. Ethanol-treated rats showed mean blood ethanol concentrations between 60-90 mg/dl. Alcohol treatment did not effect the body growth rate, but increased the DNA synthesis in lactotropes and reduced the levels of lactotropic growth inhibitory transforming growth factor-beta 1 (TGF-beta 1) protein and mRNA in the pituitary. These results suggest that alcohol promotes estrogen-induced lactotropic proliferation, possibly by down regulating the inhibitory TGF-beta 1 control of lactotropic function.
在Fischer 344大鼠中研究了酒精对雌激素调节的促乳细胞增殖的影响。使用含8.7%乙醇（体积/体积）和37%乙醇衍生热量的液体饲料给予酒精2周。对照组给予不含乙醇的等热量饲料配对喂养或给予正常饲料自由采食。经乙醇处理的大鼠平均血液乙醇浓度在60 - 90mg/dl之间。酒精处理不影响身体生长速率，但增加了促乳细胞中的DNA合成，并降低了垂体中促乳生长抑制性转化生长因子-β1（TGF-β1）蛋白和mRNA的水平。这些结果表明，酒精可能通过下调对促乳功能的抑制性TGF-β1控制来促进雌激素诱导的促乳细胞增殖。
