金霉素在韩国耕地土壤中的命运。

Fate of chlortetracycline in Korean arable soil.

机构信息

National Veterinary Research & Quarantine Service (NVRQS), 620-2 Amnam-dong, Seo-gu, Busan, Republic of Korea.

出版信息

Bull Environ Contam Toxicol. 2011 Jul;87(1):36-9. doi: 10.1007/s00128-011-0298-8. Epub 2011 May 7.

Abstract

The widespread use of the pharmaceutical chlortetracycline to treat human and animal infectious diseases is raising concern in Korea regarding the potential development of antibiotic-resistant bacteria. This study investigated the fate of chlortetracycline in Korean arable soils, to assess its environmental impact. The estimated half-life of chlortetracycline was 26.70-27.17 days indoors and 18.63-30.16 days outdoors. The chlortetracycline epimers and metabolites, 4-epichlortetracycline and 4-epi-anydrochlotetracycline were determined using liquid chromatography tandem mass spectroscopy. The respective concentrations of 4-epi-anydrochlotetracycline and 4-epichlortetracycline were 1.91%-9.71% and 11.12%-23.92% of the total chlortetracycline residual concentration indoors and 2.96%-11.44% and 17.61%-40.73% outdoors.

摘要

由于广泛使用药物金霉素来治疗人类和动物传染病，韩国开始担心会产生抗药性细菌。本研究旨在探讨金霉素在韩国耕地土壤中的命运，以评估其对环境的影响。结果表明，金霉素在室内的半衰期估计为 26.70-27.17 天，在室外的半衰期为 18.63-30.16 天。利用液相色谱串联质谱法测定了金霉素差向异构体和代谢物 4-差向金霉素和 4-差向脱水金霉素的浓度。室内金霉素总残留浓度的 4-差向脱水金霉素和 4-差向金霉素的浓度分别为 1.91%-9.71%和 11.12%-23.92%，室外浓度分别为 2.96%-11.44%和 17.61%-40.73%。