Laboratoire des Bioprocédés Environnemtaux, Pôle d'excellence régional AUF (PER-LBP), Center de biotechnologie de Sfax (CBS), Université de Sfax, BP:1177, 3038, Sfax, Tunisia.
Endocrine. 2011 Dec;40(3):462-71. doi: 10.1007/s12020-011-9483-0. Epub 2011 May 8.
Iron liver excess is associated to biochemical and histological liver perturbations. Our aim was to know even if fresh garlic consumption can remediate these problems. Three groups of rats were utilized: control group A, iron overload group B and garlic and iron overload group C. Important morphological and biochemical modifications were obtained in group B rats comparatively to control group A. Indeed, body and liver weights and liver iron contents increased, respectively, by 12.5 ± 0.06%; 17 ± 0.25% and 35 ± 0.11% comparatively to controls. Radical cation scavenging ability in liver cytosol of group B rats was significantly low (54 ± 0,1%) in comparison to group A. Garlic consumption allowed the group C to achieve an increase by 46 ± 0,11 and 75 ± 0,14% of total antioxidant capacity comparatively to group A and B rats. For the serum ALAT, ASAT, triglyceride and LDH levels, they increased in iron-treated rats, respectively, by 25 ± 0.21; 15 ± 0.12; 30 ± 0.14 and 22 ± 0.16% comparatively to controls. These perturbations were accompanied by deep histological changes. After food fresh garlic supplementation, we had found a deep regulation of all modified parameters showing a hepatoprotective effect of garlic against iron liver excess. Garlic chemical compounds have curative effects on iron liver excess.
铁肝过载与生化和组织学肝扰动有关。我们的目的是了解新鲜大蒜的消费是否可以改善这些问题。使用了三组大鼠：对照组 A、铁过载组 B 和大蒜和铁过载组 C。与对照组 A 相比，B 组大鼠获得了重要的形态和生化改变。事实上，体重和肝脏重量以及肝脏铁含量分别增加了 12.5 ± 0.06%；17 ± 0.25%和 35 ± 0.11%。与对照组相比，B 组大鼠肝胞浆中自由基阳离子清除能力显著降低（54 ± 0.1%）。大蒜的消耗使 C 组大鼠的总抗氧化能力分别比 A 组和 B 组大鼠增加了 46 ± 0.11%和 75 ± 0.14%。对于血清中的 ALAT、ASAT、甘油三酯和 LDH 水平，铁处理大鼠分别增加了 25 ± 0.21%；15 ± 0.12%；30 ± 0.14%和 22 ± 0.16%。这些变化伴随着深刻的组织学变化。在食用新鲜大蒜补充剂后，我们发现所有受调节参数都得到了深刻的调节，表明大蒜对铁肝过载具有保护作用。大蒜的化学化合物对铁肝过载具有治疗作用。
