Institut Charles Gerhardt Montpellier, Equipe Ingénierie et Architectures Macromoléculaires, Université Montpellier II cc1702, Montpellier Cedex 5, France.
Biomacromolecules. 2011 Jun 13;12(6):1973-82. doi: 10.1021/bm2004803. Epub 2011 May 17.
This Review is focused on the growing interest brought to phosphorus-containing organic materials for applications in the biomedical field, mainly because of their properties such as biocompatibility, hemocompatibility, and protein adsorption resistance. It mainly describes relevant works achieved on these materials for various applications: dentistry, regenerative medicine, and drug delivery. Special attention was given to 2-methacryloyloxyethyl phosphorylcholine (MPC) monomer as the latter appeared of great importance because of its biomimetic structure due to the presence of the phospholipid group on its structure. As a result, much research effort is currently concentrated on the development of phosphorylcholine-containing (co)polymers that represent a promising class of materials.
这篇综述重点介绍了含磷有机材料在生物医学领域应用的日益增长的兴趣，主要是因为它们具有生物相容性、血液相容性和抗蛋白质吸附性等特性。本文主要描述了这些材料在各种应用中的相关工作：牙科、再生医学和药物输送。特别关注 2-（甲基丙烯酰氧）乙基磷酸胆碱（MPC）单体，因为其结构中存在磷脂基团，具有仿生结构，因此显得尤为重要。因此，目前大量的研究工作集中在开发含磷酰胆碱（共）聚合物，这是一类很有前途的材料。
