Department of Genetics, Harvard Medical School, Boston, Massachusetts 02114-2790, USA.
J Integr Plant Biol. 2011 Jun;53(6):469-79. doi: 10.1111/j.1744-7909.2011.01044.x.
Jin-Gui Chen (Corresponding author) Abscisic acid (ABA) is the key plant stress hormone. Consistent with the earlier studies in support of the presence of both membrane- and cytoplasm-localized ABA receptors, recent studies have identified multiple ABA receptors located in various subcellular locations. These include a chloroplast envelope-localized receptor (the H subunit of Chloroplast Mg(2+) -chelatase/ABA Receptor), two plasma membrane-localized receptors (G-protein Coupled Receptor 2 and GPCR-type G proteins), and one cytosol/nucleus-localized Pyrabactin Resistant (PYR)/PYR-Like (PYL)/Regulatory Component of ABA Receptor 1 (RCAR). Although the downstream molecular events for most of the identified ABA receptors are currently unknown, one of them, PYR/PYL/RCAR was found to directly bind and regulate the activity of a long-known central regulator of ABA signaling, the A-group protein phosphatase 2C (PP2C). Together with the Sucrose Non-fermentation Kinase Subfamily 2 (SnRK2s) protein kinases, a central signaling complex (ABA-PYR-PP2Cs-SnRK2s) that is responsible for ABA signal perception and transduction is supported by abundant genetic, physiological, biochemical and structural evidence. The identification of multiple ABA receptors has advanced our understanding of ABA signal perception and transduction while adding an extra layer of complexity.
陈进桂（通讯作者）脱落酸（ABA）是关键的植物应激激素。与早期支持存在质膜和细胞质定位 ABA 受体的研究一致，最近的研究已经鉴定出位于各种亚细胞位置的多个 ABA 受体。这些包括叶绿体被膜定位受体（叶绿体镁螯合酶/ABA 受体的 H 亚基）、两个质膜定位受体（G 蛋白偶联受体 2 和 GPCR 型 G 蛋白）和一个细胞质/核定位 Pyrabactin 抗性（PYR）/PYR 样（PYL）/ABA 受体调节元件 1（RCAR）。虽然大多数已鉴定的 ABA 受体的下游分子事件目前尚不清楚，但其中之一 PYR/PYL/RCAR 被发现直接结合并调节 ABA 信号通路中一个已知的中央调节剂 A 组蛋白磷酸酶 2C（PP2C）的活性。大量的遗传、生理、生化和结构证据支持一个中央信号复合物（ABA-PYR-PP2Cs-SnRK2s），该复合物由蔗糖非发酵激酶亚家族 2（SnRK2s）蛋白激酶组成，负责 ABA 信号感知和转导。多个 ABA 受体的鉴定提高了我们对 ABA 信号感知和转导的理解，同时增加了一层复杂性。
