Bernstein Center for Computational Neuroscience, Göttingen, Germany.
Neuron. 2011 May 12;70(3):536-48. doi: 10.1016/j.neuron.2011.02.053.
In natural situations, movements are often directed toward locations different from that of the evoking sensory stimulus. Movement goals must then be inferred from the sensory cue based on rules. When there is uncertainty about the rule that applies for a given cue, planning a movement involves both choosing the relevant rule and computing the movement goal based on that rule. Under these conditions, it is not clear whether primates compute multiple movement goals based on all possible rules before choosing an action, or whether they first choose a rule and then only represent the movement goal associated with that rule. Supporting the former hypothesis, we show that neurons in the frontoparietal reach areas of monkeys simultaneously represent two different rule-based movement goals, which are biased by the monkeys' choice preferences. Apparently, primates choose between multiple behavioral options by weighing against each other the movement goals associated with each option.
在自然情境中，运动的方向通常与引起感觉刺激的位置不同。因此，运动目标必须根据规则从感觉提示中推断出来。当对于给定的提示，不确定适用哪个规则时，规划运动既涉及选择相关规则，又涉及根据该规则计算运动目标。在这些条件下，尚不清楚灵长类动物是否在选择行动之前，基于所有可能的规则计算多个运动目标，还是首先选择一个规则，然后仅表示与该规则相关的运动目标。支持前一种假说，我们表明猴子的顶侧和顶侧到达区域的神经元同时表示两种不同的基于规则的运动目标，这些目标受到猴子选择偏好的影响。显然，灵长类动物通过相互权衡每个选项相关的运动目标来在多个行为选项之间进行选择。
