Clinical Diabetes and Epidemiology Department, Baker IDI Heart and Diabetes Institute, Melbourne, Victoria, Australia.
Int J Obes (Lond). 2012 Feb;36(2):295-303. doi: 10.1038/ijo.2011.103. Epub 2011 May 10.
To assess the prospective relationship between obesity and health-related quality of life, including a novel assessment of the impact of health-related quality of life on weight gain.
Longitudinal, national, population-based Australian Diabetes, Obesity and Lifestyle (AusDiab) study, with surveys conducted in 1999/2000 and 2004/2005.
A total of 5985 men and women aged ≥ 25 years at study entry.
MAIN OUTCOME MEASURE(S): At both time points, height, weight and waist circumference were measured and self-report data on health-related quality of life from the SF-36 questionnaire were obtained. Cross-sectional and bi-directional, prospective associations between obesity categories and health-related quality of life were assessed.
Higher body mass index (BMI) at baseline was associated with deterioration in health-related quality of life over 5 years for seven of the eight health-related quality of life domains in women (all P ≤ 0.01, with the exception of mental health, P>0.05), and six out of eight in men (all P<0.05, with the exception of role-emotional, P=0.055, and mental health, P>0.05). Each of the quality-of-life domains related to mental health as well as the mental component summary were inversely associated with BMI change (all P<0.0001 for women and P ≤ 0.01 for men), with the exception of vitality, which was significant in women only (P=0.008). For the physical domains, change in BMI was inversely associated with baseline general health in women only (P=0.023).
Obesity was associated with a deterioration in health-related quality of life (including both physical and mental health domains) in this cohort of Australian adults followed over 5 years. Health-related quality of life was also a predictor of weight gain over 5 years, indicating a bi-directional association between obesity and health-related quality of life. The identification of those with poor health-related quality of life may be important in assessing the risk of future weight gain, and a focus on health-related quality of life may be beneficial in weight management strategies.
评估肥胖与健康相关生活质量之间的前瞻性关系，包括对健康相关生活质量对体重增加影响的新评估。
在 1999/2000 年和 2004/2005 年进行的澳大利亚糖尿病、肥胖和生活方式（AusDiab）研究的纵向、全国性、基于人群的研究，在研究开始时对 5985 名年龄≥25 岁的男性和女性进行了调查。
共有 5985 名年龄≥25 岁的男性和女性在研究开始时参与了研究。
在两个时间点，测量身高、体重和腰围，并从 SF-36 问卷中获得与健康相关的生活质量的自我报告数据。评估肥胖类别与健康相关生活质量之间的横断面和双向前瞻性关联。
女性中，基线时较高的体重指数（BMI）与 5 年内 8 个健康相关生活质量领域中的 7 个领域的健康相关生活质量恶化相关（所有 P≤0.01，心理健康除外，P＞0.05），男性中，6 个领域与 8 个领域相关（所有 P＜0.05，除了角色情感，P=0.055，心理健康，P＞0.05）。与心理健康相关的所有生活质量领域以及心理成分综合评分均与 BMI 变化呈负相关（女性均为 P＜0.0001，男性均为 P≤0.01），除了活力，仅在女性中具有统计学意义（P=0.008）。对于身体领域，BMI 的变化与女性基线时的总体健康状况呈负相关（P=0.023）。
在这项对澳大利亚成年人进行的为期 5 年的随访研究中，肥胖与健康相关生活质量（包括身体和心理健康领域）的恶化有关。健康相关生活质量也是 5 年内体重增加的预测因素，表明肥胖与健康相关生活质量之间存在双向关联。识别那些健康相关生活质量差的人可能对评估未来体重增加的风险很重要，关注健康相关生活质量可能有益于体重管理策略。
