Boulikas T
Int J Oncol. 1995 Jun;6(6):1313-8. doi: 10.3892/ijo.6.6.1313.
The sites of attachment of chromatin loops to the nuclear matrix (MARs) seem to harbor transcriptional enhancers, promoters and origins of replication (ORIs). According to the model proposed, the cooperative interactions among classical nuclear matrix proteins which are abundant (topoisomerase II, histone H1, HMG-I(Y), lamins A, B1, SAF-A, ARBP and others) bring together distant AT-rich classical MAR sequences causing looping of DNA. This process juxtaposes enhancers, ORIs, promoters, and other control elements that cohabit with MARs loaded with the less abundant transcription factors (TFs) facilitating productive interactions between enhancers and promoters or enhancers and core ORIs. The implications of the model in the interactions of oncoproteins with regulatory DNA elements and their integration into a chromatin and nuclear matrix environment are discussed.
染色质环与核基质（MARs）的附着位点似乎含有转录增强子、启动子和复制起点（ORIs）。根据提出的模型，丰富的经典核基质蛋白（拓扑异构酶II、组蛋白H1、HMG-I(Y)、核纤层蛋白A、B1、SAF-A、ARBP等）之间的协同相互作用使远距离富含AT的经典MAR序列聚集在一起，导致DNA形成环。这个过程使增强子、ORIs、启动子和其他调控元件并列，这些元件与负载较少丰度转录因子（TFs）的MARs共存，促进增强子与启动子或增强子与核心ORIs之间的有效相互作用。讨论了该模型在癌蛋白与调控DNA元件相互作用及其整合到染色质和核基质环境中的意义。
