Tepperman B L, Soper B D
Department of Physiology, Faculty of Medicine, University of Western Ontario, London, Canada.
Can J Physiol Pharmacol. 1990 Feb;68(2):207-10. doi: 10.1139/y90-032.
We have observed that removal of the salivary glands is associated with an increase in the susceptibility to gastric mucosal damage in the rat. In the present study, we have examined the effect of sialoadenectomy on ethanol-induced mucosal hemorrhagic damage and myeloperoxidase (MPO) activity. Hemorrhagic damage and MPO activity in response to intragastric 50% w/v ethanol were greater in sialoadenectomized rats when compared with sham-operated animals. Pretreatment with 16,16-dimethylprostaglandin E2 (0.3 micrograms/kg s.c.) reduced damage and MPO activity in both sialoadenectomized and sham control rats receiving 50% ethanol. The reduction in these parameters was greater in control than in sialoadenectomized rats. Pretreatment with epidermal growth factor (5 micrograms/kg s.c.) significantly reduced MPO activity but did not significantly affect the extent of damage. These data suggest that sialoadenectomy is associated with an increase in mucosal inflammation in animals given ethanol. However, in some situations tissue inflammation (as indicated by MPO activity) was reduced, while the proportion of gastric mucosa exhibiting hemorrhagic damage was not changed.
我们观察到，切除大鼠唾液腺会使其对胃黏膜损伤的易感性增加。在本研究中，我们检测了涎腺切除对乙醇诱导的黏膜出血性损伤和髓过氧化物酶（MPO）活性的影响。与假手术动物相比，涎腺切除大鼠对胃内50%（w/v）乙醇所致的出血性损伤和MPO活性更高。用16,16-二甲基前列腺素E2（0.3微克/千克，皮下注射）预处理可降低接受50%乙醇的涎腺切除大鼠和假手术对照大鼠的损伤和MPO活性。这些参数在对照大鼠中的降低幅度大于涎腺切除大鼠。用表皮生长因子（5微克/千克，皮下注射）预处理可显著降低MPO活性，但对损伤程度无显著影响。这些数据表明，涎腺切除与给予乙醇的动物黏膜炎症增加有关。然而，在某些情况下，组织炎症（以MPO活性表示）降低，而出现出血性损伤的胃黏膜比例未改变。
