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从纳米压痕测试中获取胶原纤维的横向力学性能。

Transverse mechanical properties of collagen fibers from nanoindentation.

机构信息

Laboratory of Mechanics, Aristotle University of Thessaloniki, 54-124 Thessaloniki, Greece.

出版信息

J Mater Sci Mater Med. 2011 Jun;22(6):1375-81. doi: 10.1007/s10856-011-4320-9. Epub 2011 May 10.

DOI:10.1007/s10856-011-4320-9
PMID:21556981
Abstract

The mechanical properties of collagenous tissues, such as tendon and ligaments, are of particular interest as they are found extensively in the human body. In the present study the transverse mechanical properties of collagen fibers are reported for the first time. The elastic modulus was found to be 63 ± 4 MPa, while the viscosity was estimated to be 14 GPa ≤ η ≤ 56 GPa s. Comparison with similar data in the literature, for bulk tendon and collagen fibrils, suggests that the apparent modulus of a network of interconnected building blocks is reduced as compared to the modulus of the individual building blocks; in particular E (tendon) < E (fiber) < E (fibril); this is due to the fact that as the scale of the microstructure increases (i) slippage and sliding between the respective building blocks (fibrils or fibers) increases, (ii) the volume fraction of the stiff collagen proteins decreases.

摘要

胶原组织(如肌腱和韧带)的力学性能特别重要,因为它们在人体中广泛存在。本研究首次报道了胶原纤维的横向力学性能。发现其弹性模量为 63 ± 4 MPa,而黏度估计为 14 GPa ≤ η ≤ 56 GPa s。与文献中类似的肌腱和胶原原纤维的整体数据相比,这表明与单个构建块的模量相比,相互连接的构建块网络的表观模量降低;具体而言,E(肌腱)<E(纤维)<E(原纤维);这是由于随着微观结构的尺度增加(i)各构建块(原纤维或纤维)之间的滑动和滑动增加,(ii)刚性胶原蛋白的体积分数减少。

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本文引用的文献

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Nanomechanical properties of thin films of type I collagen fibrils.I 型胶原原纤维薄膜的纳米力学性能。
Langmuir. 2010 Mar 2;26(5):3629-36. doi: 10.1021/la903073v.
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Nanoindentation of the insertional zones of human meniscal attachments into underlying bone.人半月板附着于下方骨骼的插入区域的纳米压痕试验
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Nanoscale viscoelastic properties of an aligned collagen scaffold.排列的胶原蛋白支架的纳米级粘弹性特性
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The effects of maturation and aging on the rotator cuff tendon-to-bone interface.成熟和老化对肩袖肌腱-骨界面的影响。
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Integrating structural heterogeneity, fiber orientation, and recruitment in multiscale ECM mechanics.多尺度 ECM 力学中整合结构异质性、纤维方向和募集
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Sci Rep. 2018 Jul 4;8(1):10126. doi: 10.1038/s41598-018-28293-1.
10
The Role of Network Architecture in Collagen Mechanics.网络架构在胶原蛋白力学中的作用。
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Mechanical properties of collagen fibrils.胶原纤维的力学性能。
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5
Bi-directional mechanical properties of the posterior region of the glenohumeral capsule.盂肱关节囊后部的双向力学特性。
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Flexibility of type I collagen and mechanical property of connective tissue.I型胶原蛋白的柔韧性与结缔组织的力学性能。
Biorheology. 2004;41(3-4):239-46.
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Bi-directional mechanical properties of the axillary pouch of the glenohumeral capsule: implications for modeling and surgical repair.盂肱关节囊腋袋的双向力学特性:对建模和手术修复的启示
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Nanoindentation of soft hydrated materials for application to vascular tissues.用于血管组织的柔软水合材料的纳米压痕技术。
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