Bose Shirsha, Li Simin, Mele Elisa, Silberschmidt Vadim V
Wolfson School of Mechanical, Electrical and Manufacturing Engineering, Loughborough University, Loughborough LE11 3TU, Leicestershire, UK.
Department of Materials, Loughborough University, Loughborough LE11 3TU, Leicestershire, UK.
Materials (Basel). 2022 Apr 8;15(8):2753. doi: 10.3390/ma15082753.
Collagen is the basic protein of animal tissues and has a complex hierarchical structure. It plays a crucial role in maintaining the mechanical and structural stability of biological tissues. Over the years, it has become a material of interest in the biomedical industries thanks to its excellent biocompatibility and biodegradability and low antigenicity. Despite its significance, the mechanical properties and performance of pure collagen have been never reviewed. In this work, the emphasis is on the mechanics of collagen at different hierarchical levels and its long-term mechanical performance. In addition, the effect of hydration, important for various applications, was considered throughout the study because of its dramatic influence on the mechanics of collagen. Furthermore, the discrepancies in reports of the mechanical properties of collagenous tissues (basically composed of 20-30% collagen fibres) and those of pure collagen are discussed.
胶原蛋白是动物组织的基本蛋白质，具有复杂的层次结构。它在维持生物组织的机械和结构稳定性方面起着至关重要的作用。多年来，由于其优异的生物相容性、生物降解性和低抗原性，它已成为生物医学行业中备受关注的材料。尽管其具有重要意义，但纯胶原蛋白的机械性能和表现从未被综述过。在这项工作中，重点是不同层次水平的胶原蛋白力学及其长期机械性能。此外，由于水合作用对胶原蛋白力学有显著影响，在整个研究过程中都考虑了其对各种应用的重要性。此外，还讨论了胶原组织（基本由20 - 30%的胶原纤维组成）和纯胶原蛋白机械性能报告中的差异。
