皮下注射与鼻内注射降钙素的急性效果比较。

A comparison of the acute effects of subcutaneous and intranasal calcitonin.

作者信息

O'Doherty D P, Bickerstaff D R, McCloskey E V, Atkins R, Hamdy N A, Kanis J A

机构信息

Department of Human Metabolism and Clinical Biochemistry, University of Sheffield Medical School, Sheffield, U.K.

出版信息

Clin Sci (Lond). 1990 Feb;78(2):215-9. doi: 10.1042/cs0780215.

DOI:10.1042/cs0780215

Abstract

We studied the acute effects of intranasal and subcutaneous calcitonin in 40 patients with active Paget's disease of bone. Patients received a single dose of either 400 units of calcitonin delivered as a nasal spray, or 1, 10 or 100 units of subcutaneous calcitonin, or placebo. 2. Subcutaneous salmon calcitonin, administered at doses of 1, 10 and 100 units to nine patients with Paget's disease of bone, induced a dose-dependent fall in the serum calcium. This calcium-lowering effect was not seen with a second group of nine patients receiving placebo. 3. The lower doses of calcitonin had significant effects, and these were more pronounced in patients with lower rates of bone turnover. 4. Four hundred units of calcitonin administered as a nasal spray induced effects qualitatively similar to those seen with subcutaneous calcitonin, with an efficacy equivalent to approximately 30 units of subcutaneous calcitonin. 5. We conclude that the bioequivalence of calcitonin given by intranasal insufflation is low compared with its parenteral administration. The intranasal route may be more appropriate for managing patients with disorders associated with low bone turnover.

摘要

我们研究了鼻内和皮下注射降钙素对40例活动期骨Paget病患者的急性影响。患者接受单剂量的400单位降钙素鼻喷雾剂、1、10或100单位皮下降钙素或安慰剂。2. 对9例骨Paget病患者皮下注射1、10和100单位的鲑鱼降钙素，可导致血清钙呈剂量依赖性下降。接受安慰剂的另一组9例患者未观察到这种降钙作用。3. 较低剂量的降钙素具有显著作用，在骨转换率较低的患者中更为明显。4. 400单位降钙素鼻喷雾剂产生的效果在性质上与皮下注射降钙素相似，其疗效相当于约30单位皮下降钙素。5. 我们得出结论，与胃肠外给药相比，经鼻内注入降钙素的生物等效性较低。鼻内途径可能更适合于治疗与低骨转换相关疾病的患者。