血管紧张素转换酶抑制状态下慢性肾病患者二巯基丁二酸的肾脏摄取及肾小球滤过率
Renal uptake of dimercaptosuccinic acid and glomerular filtration rate in chronic nephropathy at angiotensin converting enzyme inhibition.
作者信息
Kamper A L, Thomsen H S, Nielsen S L, Strandgaard S
机构信息
Department of Nephrology, Herlev Hospital, University of Copenhagen, Denmark.
出版信息
Eur J Nucl Med. 1990;16(2):85-8. doi: 10.1007/BF01465915.
Glomerular filtration rate (GFR) and renal uptake of dimercaptosuccinic acid (DMSA) were measured in 31 patients with progressive chronic nephropathy before and immediately after the start of treatment with angiotensin converting enzyme (ACE) inhibitor in order to control adverse effects on kidney function. Scintigrams of the kidneys showed an unaltered distribution of DMSA during treatment. GFR estimated by 51Cr-EDTA plasma clearance fell by 14% (P less than 0.01), but renal uptake of 99mTc-DMSA increased by 10% (P less than 0.01). It is concluded that DMSA in chronic renal failure is mainly taken up by the tubular cells from the peritubular capillaries since the uptake was unaffected by the acute decrease in GFR.
对31例进行性慢性肾病患者在开始使用血管紧张素转换酶（ACE）抑制剂治疗前及治疗后立即测量肾小球滤过率（GFR）和二巯基丁二酸（DMSA）的肾摄取，以控制对肾功能的不良反应。肾脏闪烁扫描显示治疗期间DMSA的分布未改变。通过51Cr-EDTA血浆清除率估算的GFR下降了14%（P<0.01），但99mTc-DMSA的肾摄取增加了10%（P<0.01）。得出的结论是，慢性肾衰竭中的DMSA主要由肾小管周围毛细血管中的肾小管细胞摄取，因为摄取不受GFR急性下降的影响。
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