de Lange M J, Piers D A, Kosterink J G, van Luijk W H, Meijer S, de Zeeuw D, van der Hem G K
Department of Nuclear Medicine, University Hospital, Groningen, The Netherlands.
J Nucl Med. 1989 Jul;30(7):1219-23.
The finding of an enhanced excretion of [99mTc]dimercaptosuccinic acid (DMSA) in patients with tubular reabsorption disorders prompted us to investigate the role of filtration in the renal handling of [99mTc]DMSA. Our studies in human serum indicated that binding to serum proteins was approximately 90%. Chromatography of human urine and studies in rats showed that the complex was excreted unaltered into the urine. Renal extraction of [99mTc]DMSA in a human volunteer was 5.8%. Continuous infusion of [99mTc]DMSA in 13 individuals with normal renal function gave the following results (mean +/- s.d.): plasma clearance of [99mTc]DMSA 34 +/- 4 ml/min, urinary clearance of [99mTc]DMSA 12 +/- 3 ml/min. The calculated filtered load of [99mTc]DMSA closely resembled the urinary clearance, whereas the plasma clearance was about three times faster. This indicates that peritubular uptake accounts for approximately 65% and filtration for approximately 35% of the renal handling of [99mTc]DMSA.
在肾小管重吸收障碍患者中发现[99mTc]二巯基丁二酸（DMSA）排泄增加，促使我们研究滤过在肾脏处理[99mTc]DMSA中的作用。我们对人血清的研究表明，与血清蛋白的结合率约为90%。对人尿液的色谱分析及在大鼠中的研究显示，该复合物原样排泄到尿液中。一名人类志愿者的[99mTc]DMSA肾脏摄取率为5.8%。对13名肾功能正常的个体持续输注[99mTc]DMSA，结果如下（均值±标准差）：[99mTc]DMSA的血浆清除率为34±4 ml/分钟，[99mTc]DMSA的尿液清除率为12±3 ml/分钟。计算得出的[99mTc]DMSA滤过负荷与尿液清除率非常相似，而血浆清除率约快三倍。这表明，肾小管周围摄取约占肾脏处理[99mTc]DMSA的65%，滤过约占35%。
